2-(4-methoxy-benzyloxy)-aniline | 106272-20-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-methoxy-benzyloxy)-aniline
• 英文别名: 2-(4-Methoxy-benzyloxy)-anilin；2-[(4-Methoxyphenyl)methoxy]aniline
• CAS: 106272-20-2
• 化学式: C₁₄H₁₅NO₂
• mdl: MFCD08699316
• 分子量: 229.279
• InChiKey: MKSOKORSNCKAAE-UHFFFAOYSA-N

物化性质

• 沸点：
  385.3±22.0 °C(Predicted)
• 密度：
  1.143±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-methoxy-benzyloxy)-aniline 在 二叔丁基过氧化物 、 iron(II) bromide 作用下， 以 苯 为溶剂， 以87%的产率得到2-(4-甲氧基苯基)-1,3-苯并恶唑
  参考文献：
  名称：

  氧原子邻位CH键氧化合成2-芳基苯并恶唑

  摘要：

  开发了一种从容易获得的底物合成苯并恶唑的实用且简单的方法。该协议由来自简单醚衍生物的铁催化串联氧化过程触发。

  DOI：

  10.1002/ejoc.201301504
• 作为产物：
  描述：

  1-碘-2-[(4-甲氧基苯基)甲氧基]苯 在 copper(l) iodide 、 sodium azide 、 N,N'-二甲基乙二胺 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以52%的产率得到2-(4-methoxy-benzyloxy)-aniline
  参考文献：
  名称：

  铜介导的胺化反应合成 8-氨基-(二氢呋喃-稠合全氢菲)

  摘要：

  Introduction of nitrogen substituents on a highly functionalized dihydrofuran-fused perhydrophenanthrene (DF) core was examined. Acetamide functionality could be introduced on the DF by copper-mediated Buchwald-type coupling. On the other hand, installation of free amino group on a DF was established via an aryl azide under the copper-mediated condition reported by Helquist and co-workers.

  DOI：

  10.3987/com-13-s(s)38

文献信息

• Cavill et al., Journal of the Chemical Society, 1958, p. 1544,1548
  作者：Cavill et al.

  DOI：——

  日期：——
• Synthesis of substituted 6H-benzo[c]chromenes: a palladium promoted ring closure of diazonium tetrafluoroborates
  作者：Jing Zhou、Liang-Zhu Huang、You-Qiang Li、Zhen-Ting Du

  DOI：10.1016/j.tetlet.2012.10.038

  日期：2012.12

  A highly efficient palladium-catalysed phenyl diazonium tetrafluoroborate participation of C-H activation ring closure protocol has been developed. A series of 6H-benzo[c]chromenes have been synthesized by intramolecular cyclization of ortho diazonium salts tetrafluoroborate of benzyloxyphenyl (Method A), or phenoxymethyl phenyl (Method B). The transformation allows the synthesis of 6H-benzo[c]chromenes with a wide variety of functional groups and substitution patterns from simple and easily accessible precursors. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
• Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S
  申请人：Diamond Scott L.

  公开号：US20110207726A1

  公开（公告）日：2011-08-25

  The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
• [EN] INHIBITORS OF HUMAN CATHEPSIN L, CATHEPSIN B, AND CATHEPSIN S<br/>[FR] INHIBITEURS DES CATHEPSINES L, B ET S HUMAINES
  申请人：UNIV PENNSYLVANIA

  公开号：WO2009136997A2

  公开（公告）日：2009-11-12

  The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.