N-(5-aminopentyl)-2,2,2-trifluoroacetamide | 183724-35-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(5-aminopentyl)-2,2,2-trifluoroacetamide
• CAS: 183724-35-8
• 化学式: C₇H₁₃F₃N₂O
• 分子量: 198.188
• InChiKey: YSGNIOUCBHVYJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(5-aminopentyl)-2,2,2-trifluoroacetamide 、 生成 9-(2-methoxyethyl)-N-[5-[(2,2,2-trifluoroacetyl)amino]pentyl]-5,6,7,8-tetrahydrocarbazole-3-carboxamide
  参考文献：
  名称：

  EP1184373

  摘要：

  公开号：
• 作为产物：
  描述：

  三氟乙酸乙酯 、 1,5-diaminopentane dihydrochloride 在 potassium tert-butylate 作用下， 以 二氯甲烷 为溶剂， 生成 N-(5-aminopentyl)-2,2,2-trifluoroacetamide
  参考文献：
  名称：

  High Yield Selective Acylation of Polyamines:  Proton as Protecting Group

  摘要：

  An advance in the selective acylation of polyamines having identical or similar amine functions is reported. While nucleophilicity differences between the various amine functions are slight, the corresponding conjugate acids exhibit pK(a) values over a significant range. We have used proton as polyamine protecting group: the monoamine resulting from single deprotonation of a polyammonium compound has allowed for high yields of selective acylation.

  DOI：

  10.1021/ol702206d

文献信息

• SOLID SUPPORTS AND PHOSPHORAMIDITE BUILDING BLOCKS FOR OLIGONUCLEOTIDE CONJUGATES
  申请人：AM Chemicals LLC

  公开号：US20180016232A1

  公开（公告）日：2018-01-18

  Novel non-nucleoside solid supports and phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one non-nucleosidic moiety conjugated to a ligand of practical interest and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said solid supports and phosphoramidite building blocks, preferably followed by removal of protecting groups to provide oligonucleotides conjugated to ligands of interest.

  揭示了用于制备含有至少一个非核苷酸基团与实用兴趣配体共轭的合成寡核苷酸的新型非核苷酸固相支持体和磷酰胺酸酯构建块，以及制备这些固相支持体和磷酰胺酸酯构建块的合成过程。此外，使用所述固相支持体和磷酰胺酸酯构建块制备寡聚合物化合物，最好是在去除保护基的情况下，以提供与感兴趣的配体共轭的寡核苷酸。
• [EN] SHORT PENDANT ARM LINKERS FOR NUCLEOTIDES IN SEQUENCING APPLICATIONS<br/>[FR] LIEURS DE BRAS PENDANTS COURTS POUR NUCLÉOTIDES DANS DES APPLICATIONS DE SÉQUENÇAGE
  申请人：ILLUMINA CAMBRIDGE LTD

  公开号：WO2019012080A1

  公开（公告）日：2019-01-17

  The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications. The compounds have formula (I) wherein B is a nucleoside base; and Fl is a fluorophore attached through an optional linker. More specifically the compounds have formulas (c) or (t) wherein p is a triphosphate group; and Fl is a fluorophore attached through an optional linker.

  本公开涉及新的核苷酸和寡核苷酸化合物及其在核酸测序应用中的使用。该化合物具有公式(I)，其中B是一个核苷酸碱基；Fl是通过可选连接剂连接的荧光团。更具体地，该化合物具有公式(c)或(t)，其中p是三磷酸基团；Fl是通过可选连接剂连接的荧光团。
• Solid supports and phosphoramidite building blocks for oligonucleotide conjugates
  申请人：AM Chemicals LLC

  公开号：US10781175B2

  公开（公告）日：2020-09-22

  Novel non-nucleoside solid supports and phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one non-nucleosidic moiety conjugated to a ligand of practical interest and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said solid supports and phosphoramidite building blocks, preferably followed by removal of protecting groups to provide oligonucleotides conjugated to ligands of interest.

  本发明公开了用于制备合成寡核苷酸的新型非核苷固体支持物和亚磷酰胺构筑基块，这些寡核苷酸至少含有一个与实际利益配体共轭的非核苷分子，并公开了制备这些寡核苷酸的合成工艺。此外，使用所述固体支持物和磷酰胺构筑砌块制备寡聚化合物，最好随后去除保护基团，以提供与相关配体共轭的寡核苷酸。
• Short pendant arm linkers for nucleotides in sequencing applications
  申请人：ILLUMINA CAMBRIDGE LIMITED

  公开号：US11001888B2

  公开（公告）日：2021-05-11

  The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications.

  本公开涉及新的核苷酸和寡核苷酸化合物及其在核酸测序应用中的使用。
• SHORT PENDANT ARM LINKERS FOR NUCLEOTIDES IN SEQUENCING APPLICATIONS
  申请人：Illumina Cambridge Limited

  公开号：EP3652191A1

  公开（公告）日：2020-05-20