ethyl 2-<1-<(1-methoxy-2,2-dimethylpropyl)peroxy>ethyl>propenoate | 157136-27-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 2-<1-<(1-methoxy-2,2-dimethylpropyl)peroxy>ethyl>propenoate
• 英文别名: Ethyl 3-(1-methoxy-2,2-dimethylpropyl)peroxy-2-methylidenebutanoate
• CAS: 157136-27-1
• 化学式: C₁₃H₂₄O₅
• 分子量: 260.331
• InChiKey: GZSREICKDIKSKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 2-<1-<(1-methoxy-2,2-dimethylpropyl)peroxy>ethyl>propenoate 在 三氟化硼 、 氧气 作用下， 以 正己烷 、 苯 为溶剂， 以93%的产率得到ethyl 2,3-epoxy-2-(2,2-dimethylpropyl)butanoate
  参考文献：
  名称：

  Intramolecular Homolytic Displacements. 24. Simple Access to Glycidic Esters via Induced Decomposition of Peroxyketals Derived from Ethyl 2-(1-Hydroperoxyethyl)propenoate

  摘要：

  The synthetic potential of the homolytic-induced decomposition of peroxyketals peroxyketals derived from ethyl 2-(1-hydroperoxyethyl)propenoate to access glycidic esters was demonstrated. The propagation step of this free radical chain reaction proceeds via the addition of an alkyl radical to the double bond followed by S(H)i on the peroxidic bond with the production of an oxy radical, regenerating rapidly by beta-elimination the alkyl radical responsible for the induced reaction, These reactions of elimination produce two fragments, an alkyl radical and an ester molecule, from linear ''acetalic'' radical, or they could be isomerizations in the case of cyclanyloxy radicals. In these last cases, the isomerization creates an ester function corresponding to a new protected functionality as aldehyde, acid, or alcohol.

  DOI：

  10.1021/jo00096a018
• 作为产物：
  描述：

  1,1-dimethoxy-2,2-dimethylpropane 、 ethyl 3-hydroperoxy-2-methylenebutanoate 在 对甲苯磺酸 作用下， 以88%的产率得到ethyl 2-<1-<(1-methoxy-2,2-dimethylpropyl)peroxy>ethyl>propenoate
  参考文献：
  名称：

  Intramolecular Homolytic Displacements. 24. Simple Access to Glycidic Esters via Induced Decomposition of Peroxyketals Derived from Ethyl 2-(1-Hydroperoxyethyl)propenoate

  摘要：

  The synthetic potential of the homolytic-induced decomposition of peroxyketals peroxyketals derived from ethyl 2-(1-hydroperoxyethyl)propenoate to access glycidic esters was demonstrated. The propagation step of this free radical chain reaction proceeds via the addition of an alkyl radical to the double bond followed by S(H)i on the peroxidic bond with the production of an oxy radical, regenerating rapidly by beta-elimination the alkyl radical responsible for the induced reaction, These reactions of elimination produce two fragments, an alkyl radical and an ester molecule, from linear ''acetalic'' radical, or they could be isomerizations in the case of cyclanyloxy radicals. In these last cases, the isomerization creates an ester function corresponding to a new protected functionality as aldehyde, acid, or alcohol.

  DOI：

  10.1021/jo00096a018

文献信息

• Stereoselectivity of the intramolecular homolytic substitution in the induced decomposition of methacrylic-type peroxidic compounds
  作者：Daniel Colombani、Bernard Maillard

  DOI：10.1016/0040-4020(96)00914-3

  日期：1996.11

  The stereochemistry of the oxiranes, obtained by radical induced decomposition of various peroxydic compounds, was determined by NMR spectroscopy. The stereoselectivity of the intramolecular homolytic substitution on the peroxidic bond was discussed in relation to the effect of the reaction temperature and on the influence of structural factors such as the nature of the leaving and attacking radicals

  通过自由基诱导的各种过氧化合物的分解获得的环氧乙烷的立体化学通过NMR光谱测定。讨论了分子内均质取代对过氧化键的立体选择性，涉及反应温度的影响以及结构因素如离去基团和进攻基团的性质的影响。