1-piperazinyl-N,N'-bis(2,4-dimethyl-pent-3-yl)perylene-3,4:9,10-tetracarboxylic diimide | 1083158-40-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1-piperazinyl-N,N'-bis(2,4-dimethyl-pent-3-yl)perylene-3,4:9,10-tetracarboxylic diimide
• 英文别名: 7,18-Di(pentan-3-yl)-11-piperazin-1-yl-7,18-diazaheptacyclo[14.6.2.22,5.03,12.04,9.013,23.020,24]hexacosa-1(23),2,4,9,11,13,15,20(24),21,25-decaene-6,8,17,19-tetrone
• CAS: 1083158-40-0
• 化学式: C₃₈H₃₈N₄O₄
• 分子量: 614.744
• InChiKey: XEXUIAKKBVFQNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  46
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  哌嗪 、 1-bromo-N,N-bis-(ethylpropyl)perylene-3,4,9,10-tetracarboxylic bisimide 以 甲苯 为溶剂， 反应 48.0h， 以60%的产率得到1-piperazinyl-N,N'-bis(2,4-dimethyl-pent-3-yl)perylene-3,4:9,10-tetracarboxylic diimide
  参考文献：
  名称：

  WO2008/139452

  摘要：

  公开号：

文献信息

• SELECTIVE BROMINATION OF PERYLENE DIIMIDES AND DERIVATIVES THEREOF UNDER MILD CONDITIONS
  申请人：Rybtchinski Boris

  公开号：US20100261901A1

  公开（公告）日：2010-10-14

  The present invention is directed to novel process for the preparation of regioselective perylenediimides derivatives, specifically mono and dibrominated derivatives.

  本发明涉及一种新型工艺，用于制备具有区域选择性的苝二酰亚胺衍生物，特别是单溴和双溴衍生物。
• Production method for natural red pigment
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0387739A1

  公开（公告）日：1990-09-19

  The present invention provides a production method for a natural red pigment characterized in that the plant of the apple or the like producing the red pigment is cultured to induce a callus which forms a red pigment, the resulting callus being cultured in liquid medium, preferably in the dark, to obtain an uniform cell dispersion, which is then cultured, preferably under blue light irradiation, the red pigment being collected from the resulting culture. Since the natural red pigment obtained in accordance with the method of the present invention is harmless to humans, it can be used as a colorant in foods, pharmaceuticals and other articles.

  本发明提供了一种天然红色素的生产方法，其特征在于培养产生红色素的苹果或类似植物，诱导形成红色素的胼胝体，将得到的胼胝体在液体培养基中培养，最好是在黑暗中培养，以获得均匀的细胞分散体，然后进行培养，最好是在蓝光照射下培养，从得到的培养物中收集红色素。 由于按照本发明的方法获得的天然红色素对人体无害，因此可用作食品、药品和其他物品的着色剂。
• Novel thymidylate synthase mutants
  申请人：Geurtsen, Werner, Prof. Dr.

  公开号：EP1316604A1

  公开（公告）日：2003-06-04

  Novel thymidylate synthase (TS mutants) are disclosed differing from human wild type thymidylate synthase in single, double, or multiple mutations, which show enhanced resistance to TS-inhibiting drugs like 5-fluorouracil or 5-fluoro-2-deoxyuridinemonophosphate. All these mutants can be used for the protection of normal human cell populations against the toxic manifestation of analogs that inhibited TS.

  本研究公开了新型胸苷酸合成酶（TS 突变体），这些突变体与人类野生型胸苷酸合成酶存在单突变、双突变或多突变，对 5-氟尿嘧啶或 5-氟-2-脱氧尿苷单磷酸等 TS 抑制药物的抗性增强。所有这些突变体都可用于保护正常人体细胞群免受抑制 TS 的类似物的毒性影响。
• Perylene diimides
  申请人：Yeda Research and Development Co. Ltd.

  公开号：EP2626359A1

  公开（公告）日：2013-08-14

  A perylene-diimide compound represented by the structure of formula 4: wherein R1 and R2 are the same or different comprising substituted or unsubstituted linear or branched alkyl group, substituted or unsubstituted saturated carbocyclic or heterocyclic ring or aryl; R3 is saturated or unsaturated heterocyclic ring; saturated or unsaturated carbocyclic ring, alkyl, alkylene, alkynyl, acetylene, diphenylacetylene, phenylacetylene, ethynyl-phenyl-2,2';6' 2" -terpyridine, 1,4-diethynylbenzene or Z-perylene ; and Z is 1,4 diethynylbenzene, phenyl, acetylene, aryl, cycloalkyl, heterocycle, olefin, azo, amide, C=N, N=C, carbonyl , 1,4 divinylbenzene, piperidine, 5,5'-Diethynyl-2,2'-Bipyridine dialcohol or dithiol; and optionally a metal or a metal ion is coordinated to said perylene diimide compound forming a metal complex with said compound.

  由式 4 结构代表的过烯二亚胺化合物： 其中 R1 和 R2 相同或不同，包括取代或未取代的直链或支链烷基、取代或未取代的饱和碳环或杂环或芳基； R3 是饱和或不饱和杂环、饱和或不饱和碳环、烷基、烯基、炔基、乙炔、二苯基乙炔、苯基乙炔、乙炔基苯基-2,2';6' 2" -三联吡啶、1,4-二炔基苯或 Z-珀烯；以及 Z 是 1,4-二乙炔基苯、苯基、炔基、芳基、环烷基、杂环、烯烃、偶氮、酰胺、C=N、N=C、羰基、1,4-二乙炔基苯、哌啶、5,5'-二乙炔基-2,2'-联吡啶二醇或二硫醇；以及 金属或金属离子与所述过二亚胺化合物配位，与所述化合物形成金属络合物。
• Methods and organism with increased xylose uptake
  申请人：Creatus Biosciences Inc.

  公开号：US10829789B2

  公开（公告）日：2020-11-10

  Provided herein are novel xylose transporters and their variants, as well as nucleic acid encoding the novel xylose transporters and their variants. Provided herein are also non-naturally occurring microbial organisms having increased xylose uptake and increased production of bioderived compounds using xylose as a substrate, as well as methods to make and use these microbial organisms.

  本文提供了新型木糖转运体及其变体，以及编码新型木糖转运体及其变体的核酸。本文还提供了具有更高的木糖吸收率和更高的以木糖为底物的生物衍生化合物产量的非天然存在的微生物有机体，以及制造和使用这些微生物有机体的方法。