3-methoxy-2-(methoxymethyl)-2-methylpropanoic acid methyl ester | 76257-44-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-methoxy-2-(methoxymethyl)-2-methylpropanoic acid methyl ester
• 英文别名: Methyl 3-methoxy-2-(methoxymethyl)-2-methylpropanoate
• CAS: 76257-44-8
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: RCUDLLAJUGDEPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2-二羟甲基丙酸 、 碘甲烷 在 silver(l) oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 28.0h， 生成 3-methoxy-2-(methoxymethyl)-2-methylpropanoic acid methyl ester
  参考文献：
  名称：

  WO2007/40208

  摘要：

  公开号：

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF
  申请人：NAKAI Hisao

  公开号：US20100063104A1

  公开（公告）日：2010-03-11

  It is intended to provide a compound represented by the formula (I): wherein all the symbols are as defined in the description; which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.

  本发明旨在提供一种由公式（I）表示的化合物：其中所有符号如描述中所定义的；其具有p38 MAP激酶抑制活性，其盐，其N-氧化物，其溶剂合物或其前药。本发明的化合物可用于预防或治疗疾病，其中被认为异常产生细胞因子如炎症性细胞因子或趋化因子或对它们过度反应与病理情况的发生和加重有关，换句话说，是细胞因子介导的疾病，例如炎症性疾病，呼吸系统疾病，心血管疾病，中枢神经系统疾病或类似疾病。
• Nuclear molecular imaging contrast agent
  申请人：Liang Huang Chien

  公开号：US20070154390A1

  公开（公告）日：2007-07-05

  A nuclear molecular imaging contrast agent. The nuclear imaging contrast agent comprises a polymer according to the structure of wherein, P is and 1 is not less than 1; D is a C3-30 dendritic moiety having a plurality of oxygen residue; Z is a C3-20 moiety having a plurality of functional groups, wherein the functional groups comprise carbonyl, carboxyl, amine, ester, amide, or chelate group; L is a radioisotope or analyte-specific moiety ; m is not less than two ; and at least one X is an analyte-specific moiety; the other X can be hydrogen atom.
• DENDRITIC POLYMERS AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT EMPLOYING THE SAME
  申请人：Thirumalai Dhakshanamurthy

  公开号：US20090169480A1

  公开（公告）日：2009-07-02

  A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of wherein, P is CH 2 CH 2 O 1 , and 1 is not less than 1 and j is not less than 2; D is a C 3-30 dendritic moiety having n oxygen residue, and n is not less than 3 and i is more than 1; X is C 3-30 moiety having bi-functional groups; Z is independent and includes a C 3-20 moiety having a plurality of functional group, wherein the functional groups are selected from a group consisting of carbonyl, carboxyl, amine, ester, amide, or chelate group, and Z respectively bonds with X by a group; and L is a metal cation.
• MICROBIAL GROWTH ENHANCEMENT FROM A DRY FILM ADDITIVE
  申请人：U.S. Army Research Laboratory ATTN: RERL-LOC-I

  公开号：US20150126689A1

  公开（公告）日：2015-05-07

  A hyperbranched polymer based on one or more repeating units of an AB x type monomer, wherein A and B are functional groups and x is greater than or equal to 2, wherein A reacts with, or substantially reacts with, B, wherein B is fractionally functionlized with a plurality of functional groups comprising a first functional group comprising a C 6 -C 30 alkyl chain attached to the repeating unit through a carbonyl group (C═O) via an ester linkage, a second functional group comprising a partially fluorinated or perfluorinated C 3 -C 20 alkyl chain attached to the repeating unit through a carbonyl group (C═O) via an ester linkage, and a third functional group comprising substantially one of a stabilized radical source attached to the repeating unit via a C 0 -C 6 tether, or a 5 to 8 member chloroamide heterocycle of carbon and nitrogen that is attached to the repeating unit via a C 2 -C 6 tether.
• US7262221B2
  申请人：——

  公开号：US7262221B2

  公开（公告）日：2007-08-28