3-(Thiazol-2-ylamino)propanenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(Thiazol-2-ylamino)propanenitrile
• 英文别名: 3-(1,3-thiazol-2-ylamino)propanenitrile
• 化学式: C₆H₇N₃S
• mdl: MFCD00520413
• 分子量: 153.21
• InChiKey: GIPGKWRSTJCCKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  77
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL AMINO ACID HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] NOUVEAUX DERIVES AMIDE HETEROCYCLIQUES D'AMINOACIDES UTILISES COMME INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE
  申请人：SEARLE & CO

  公开号：WO2000026195A1

  公开（公告）日：2000-05-11

  Amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors, having formula (I) and pharmaceutically acceptable salts and prodrugs, wherein: J is O or S; B is NR5R11 wherein R11 is selected from a heterocyclic ring in which at least one member of the ring is carbon and in which 1 to about 4 heteroatoms are independently selected from oxygen, nitrogen and sulfur and said heterocyclic ring may be optionally substituted.
• [EN] NOVEL HYDROXYAMIDINO CARBOXYLATE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] NOUVEAUX DERIVES D'HYDROAMIDINO CARBOXYLATE UTILISE COMME INHIBITEURS DE LA SYNTHASE DE L'OXYDE NITRIQUE
  申请人：SEARLE & CO

  公开号：WO2000044731A1

  公开（公告）日：2000-08-03

  The current invention discloses novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors. Compounds of particular interest are defined by Formula (I) wherein X, Y, A, J, R?1, R2 R3, R4, R7 and R8¿ are as described in the specification.