1,3-dihydroxyoctan-2-one | 1225200-56-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,3-dihydroxyoctan-2-one
• 英文别名: 1,3-Dihydroxyoctan-2-one
• CAS: 1225200-56-5
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: BWTPHMJAKKAMBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-dihydroxyoctan-2-one 、 苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 、 正己烷 、 异丙醇 为溶剂， 反应 2.0h， 生成 [(3S)-3-benzoyloxy-2-oxooctyl] benzoate 、 [(3R)-3-benzoyloxy-2-oxooctyl] benzoate
  参考文献：
  名称：

  Non-α-hydroxylated aldehydes with evolved transketolase enzymes

  摘要：

  研究人员用一系列线性和环状脂肪醛对之前确定的用于非磷酸化醛丙醛的转酮醇酶突变体进行了探索，并观察到了极佳的立体选择性。

  DOI：

  10.1039/b924144b
• 作为产物：
  描述：

  正己醛 、 Lithium hydroxypyruvate 在 N-甲基吗啉 作用下， 以 水 为溶剂， 反应 24.0h， 以3%的产率得到1,3-dihydroxyoctan-2-one
  参考文献：
  名称：

  Non-α-hydroxylated aldehydes with evolved transketolase enzymes

  摘要：

  研究人员用一系列线性和环状脂肪醛对之前确定的用于非磷酸化醛丙醛的转酮醇酶突变体进行了探索，并观察到了极佳的立体选择性。

  DOI：

  10.1039/b924144b

文献信息

• PROTEIN EXHIBITING FATTY ACID ELONGATION PROMOTING ACTIVITY, GENE ENCODING SAME AND USE THEREOF
  申请人：Suntory Holdings Limited

  公开号：EP2740797A1

  公开（公告）日：2014-06-11

  The present invention relates to a protein having an activity to promote fatty acid chain elongation, a polynucleotide encoding the same, etc. The present invention provides, for example, a polynucleotide containing the nucleotide sequence shown in SEQ ID NO: 1 or 4, a polynucleotide encoding a protein which consists of the amino acid sequence shown in SEQ ID NO: 2, an expression vector and a transformant, each containing such a polynucleotide, a method for preparing lipids or fatty acids by using such a transformant, or a food or the like containing lipids or fatty acids prepared by such a method.

  本发明涉及一种具有促进脂肪酸链延长活性的蛋白质、编码该蛋白质的多核苷酸等。例如，本发明提供了一种含有 SEQ ID NO: 1 或 4 所示核苷酸序列的多核苷酸、一种编码由 SEQ ID NO: 2 所示氨基酸序列组成的蛋白质的多核苷酸、一种表达载体和一种转化体（每种载体都含有这种多核苷酸）、一种使用这种转化体制备脂质或脂肪酸的方法，或一种含有用这种方法制备的脂质或脂肪酸的食品或类似物。
• Novel triacylgl ycerol biosynthesis in the cytosol of eukaryotes
  申请人：INDIAN INSTITUTE OF SCIENCE

  公开号：US20030157513A1

  公开（公告）日：2003-08-21

  This invention describes novel catalytically active cytosolic enzymes for triacylglycerol biosynthesis from eukaryotic systems. The complex from oleaginous yeast was enzymatically characterized, and was found to contain lysophosphatidic acid acyltransferase, phosphatidic acid phosphatase, diacylglycerol acyltransferase, acyl-acyl carrier protein synthetase, superoxide dismutase and acyl carrier protein. The triacylglycerol biosynthetic machinery rapidly incorporates free fatty acids as well as fatty acyl-coenzyme A into triacylglycerol and its biosynthetic intermediates. Lysophosphatidic acid acyltransferase, phosphatidic acid phosphatase and diacylglycerol acyltransferase from the complex were microsequenced. Acyl carrier protein, superoxide dismutase and diacylglycerol acyltransferase genes were cloned and expressed in bacterial system. The soluble triacylglycerol biosynthetic enzymes (lysophosphatidic acid acyltransferase, phosphatidic acid phosphatase, diacylglycerol acyltransferase) in yeast, rat adipocytes and human hepatocyte cell-line (HepG2) exist in the cytosol either as free enzymes or as a multienzyme complex.

  本发明描述了真核生物系统中用于三酰甘油生物合成的新型催化活性细胞膜酶。对来自油脂酵母的复合体进行了酶学鉴定，发现其中包含溶血磷脂酸酰基转移酶、磷脂酸磷酸酶、二酰甘油酰基转移酶、酰基载体蛋白合成酶、超氧化物歧化酶和酰基载体蛋白。三酰甘油生物合成机制可迅速将游离脂肪酸和脂肪酰辅酶 A 转化为三酰甘油及其生物合成中间体。对复合体中的溶血磷脂酸酰基转移酶、磷脂酸磷酸酶和二酰基甘油酰基转移酶进行了微测序。在细菌系统中克隆并表达了酰基载体蛋白、超氧化物歧化酶和二酰基甘油酰基转移酶基因。酵母、大鼠脂肪细胞和人类肝细胞系（HepG2）中的可溶性三酰甘油生物合成酶（溶血磷脂酸酰基转移酶、磷脂酸磷酸酶、二酰甘油酰基转移酶）以游离酶或多酶复合物的形式存在于细胞质中。
• Method of determining tumor characteristics by determining abnormal copy number or expression level of lipid-associated genes
  申请人：——

  公开号：US20040110197A1

  公开（公告）日：2004-06-10

  A method of assessing tumor characteristics in tissue samples by determining the copy number or expression level of genes associated with lipid metabolism, synthesis, or action is provided. Gene copy number may be assessed directly from chromosomal material or by determining the expression level of the gene in a tissue sample. The use of physical platforms comprising immobilized nucleic acid polymers to determine copy number or expression level of lipid associated genes by hybridization techniques is also provided.

  本研究提供了一种通过确定与脂质代谢、合成或作用相关的基因拷贝数或表达水平来评估组织样本中肿瘤特征的方法。基因拷贝数可直接从染色体材料或通过确定组织样本中基因的表达水平来评估。此外，还提供了使用由固定化核酸聚合物组成的物理平台，通过杂交技术确定脂质相关基因的拷贝数或表达水平。
• Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
  申请人：Xue Zhixiong

  公开号：US20060057690A1

  公开（公告）日：2006-03-16

  The promoter region associated with the Yarrowia lipolytica glycerol-3-phosphate O-acyltransferase (gpat) gene has been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the instant invention have been shown to be suitable to drive high-level expression of genes involved in the production of ω-3 and ω-6 fatty acids.

  与 油脂酵母 甘油-3-磷酸 O-酰基转移酶（gpat）基因相关的启动子区已被发现对油脂酵母中异源基因的表达特别有效。本发明的启动子区已被证明适用于驱动参与生产ω-3和ω-6脂肪酸的基因的高水平表达。
• ENZYMES INVOLVED IN THE TRIACYLGLYCEROL BIOSYNTHESIS IN THE CYTOSOL OF EUKARYOTES
  申请人：Bijam Biosciences Limited

  公开号：EP1425398A2

  公开（公告）日：2004-06-09