2-amino-3-pyrimidin-4-yl-propionic acid ethyl ester | 361458-27-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-3-pyrimidin-4-yl-propionic acid ethyl ester
• 英文别名: Ethyl 2-amino-3-(pyrimidin-4-YL)propanoate；ethyl 2-amino-3-pyrimidin-4-ylpropanoate
• CAS: 361458-27-7
• 化学式: C₉H₁₃N₃O₂
• 分子量: 195.221
• InChiKey: YRBGYWCFVWMVGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 2-[(diphenylmethylidene)amino]-3-(pyrimidin-4-yl)propanoate 在 溶剂黄146 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.5h， 以76%的产率得到2-amino-3-pyrimidin-4-yl-propionic acid ethyl ester
  参考文献：
  名称：

  [EN] ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF
  [FR] DERIVES D'ACRYLAMIDE SERVANT D'ANTAGONISTES DE L'INTEGRINE VLA-1, ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2005016883A3

文献信息

• Urea derivatives and methods of use thereof
  申请人：NodThera Limited

  公开号：US11345669B2

  公开（公告）日：2022-05-31

  The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.

  本公开涉及式（I）化合物：及其药学上可接受的盐、药物组合物、使用方法和制备方法。本文公开的化合物通过抑制炎性体，抑制 IL-1 家族细胞因子的成熟，可用于治疗与炎性体活性有关的疾病，如自身炎症、自身免疫性疾病和癌症等。
• CHEMICAL COMPOUNDS
  申请人：NodThera Limited

  公开号：US20200131141A1

  公开（公告）日：2020-04-30

  The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.