2-Methoxymethyl-1-phenyl-proponat-(1) | 57051-07-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methoxymethyl-1-phenyl-proponat-(1)
• 英文别名: 3-Methoxy-2-methyl-1-phenylpropan-1-ol
• CAS: 57051-07-7
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: VTBVRCTZGIEDOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-methoxy-2-methyl-1-phenylpropan-1-one 在 三正丁基氢锡 、 氯化二乙基铝 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以94%的产率得到2-Methoxymethyl-1-phenyl-proponat-(1)
  参考文献：
  名称：

  Hypercoordination of aluminum: Evidence for the implication of pentacoordinate complexes in the R2AlCl-promoted reduction of alkoxycarbonyl substrates

  摘要：

  R2AlCl-promoted reductions of alkoxycarbonyl substrates with Bu3SnH were found to proceed diastereoselectively through the formation of pentacoordinate chelate-type complexes which have been characterized by C-13 NMR spectroscopy. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00401-3

文献信息

• OREXIN RECEPTOR AGONISTS
  申请人：[en]MERCK SHARP & DOHME LLC

  公开号：WO2024107615A1

  公开（公告）日：2024-05-23

  The present invention is directed to compounds of Formula I which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
• Hypercoordination of aluminum: Evidence for the implication of pentacoordinate complexes in the R2AlCl-promoted reduction of alkoxycarbonyl substrates
  作者：Takashi Ooi、Junko Morikawa、Daisuke Uraguchi、Keiji Maruoka

  DOI：10.1016/s0040-4039(99)00401-3

  日期：1999.4

  R2AlCl-promoted reductions of alkoxycarbonyl substrates with Bu3SnH were found to proceed diastereoselectively through the formation of pentacoordinate chelate-type complexes which have been characterized by C-13 NMR spectroscopy. (C) 1999 Elsevier Science Ltd. All rights reserved.