4-Dimethylamino-benzoat | 22514-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Dimethylamino-benzoat
• 英文别名: 4-(dimethylamino)benzoate；4-dimethylamino-benzoic acid; deprotonated form；4-Dimethylaminobenzoate
• CAS: 22514-69-8
• 化学式: C₉H₁₀NO₂
• 分子量: 164.184
• InChiKey: YDIYEOMDOWUDTJ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Acetyl-5-amino-1-(4-aminophenyl)indole 、 4-Dimethylamino-benzoat 生成 N-(2-acetyl-1-(4-(4-dimethylaminobenzamido)phenyl)-1H-indol-5-yl)-4-dimethylaminobenzamide
  参考文献：
  名称：

  HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES

  摘要：

  本实施例涉及具有生理效应的化合物，例如激活造血生长因子受体。本实施例还涉及使用这些化合物来治疗各种状况、疾病和疾病，例如造血系统状况和疾病。

  公开号：

  US20120295904A1
• 作为产物：
  描述：

  4-(二甲基氨基)苯甲酰氟 在 potassium fluoride 作用下， 以 水 为溶剂， 生成 4-Dimethylamino-benzoat
  参考文献：
  名称：

  Inhibition of the hydrolysis of p-(dimethylamino)benzoyl fluoride by potassium fluoride

  摘要：

  DOI：

  10.1021/ja00244a058

文献信息

• A rapid response near-infrared ratiometric fluorescent probe for the real-time tracking of peroxynitrite for pathological diagnosis and therapeutic assessment in a rheumatoid arthritis model
  作者：Jiao Lu、Zan Li、Xinrui Zheng、Jiangkun Tan、Zhongyin Ji、Zhiwei Sun、Jinmao You

  DOI：10.1039/d0tb01970d

  日期：——

  Endogenous ONOO⁻ generation in rheumatoid arthritis mice was visualized and confirmed by the ratiometric fluorescent probe Ratio-A.

  在类风湿性关节炎小鼠中，内源性ONOO⁻生成通过比率荧光探针Ratio-A得到了可视化和确认。
• Salivary Aldehyde Dehydrogenase: Activity towards Aromatic Aldehydes and Comparison with Recombinant ALDH3A1
  作者：Joanna Giebułtowicz、Renata Wolinowska、Anna Sztybor、Monika Pietrzak、Piotr Wroczyński、Jacek Wierzchowski

  DOI：10.3390/molecules14072363

  日期：——

  A series of aromatic aldehydes was examined as substrates for salivary aldehyde dehydrogenase (sALDH) and the recombinant ALDH3A1. Para-substituted benzaldehydes, cinnamic aldehyde and 2-naphthaldehydes were found to be excellent substrates, and kinetic parameters for both salivary and recombinant ALDH were nearly identical. It was demonstrated that for the fluorogenic naphthaldehydes the only produced

  检查了一系列芳香醛作为唾液醛脱氢酶 (sALDH) 和重组 ALDH3A1 的底物。发现对位取代的苯甲醛、肉桂醛和 2-萘醛是极好的底物，唾液和重组 ALDH 的动力学参数几乎相同。已经证明，对于荧光性萘醛，在唾液中孵育后唯一产生的反应产物是羧酸盐。
• HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES
  申请人：Zhi Lin

  公开号：US20120295904A1

  公开（公告）日：2012-11-22

  The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

  本实施例涉及具有生理效应的化合物，例如激活造血生长因子受体。本实施例还涉及使用这些化合物来治疗各种状况、疾病和疾病，例如造血系统状况和疾病。
• USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS
  申请人：Bissonnette Reid P.

  公开号：US20140243324A1

  公开（公告）日：2014-08-28

  The present invention relates to uses of small molecule mimetics of hematopoietic growth factors. In particular the present invention relates to uses of small molecule mimetics of erythropoietin.

  本发明涉及使用小分子模拟血液生成生长因子的用途。特别是本发明涉及使用小分子模拟红细胞生成素的用途。
• Water-soluble aminocalix[4]arene receptors with hydrophobic and hydrophilic mouths
  作者：Satish Balasaheb Nimse、Van-Thuan Nguyen、Junghoon Kim、Hyung-Sup Kim、Keum-Soo Song、Woon-Young Eoum、Chan-Yong Jung、Van-Thao Ta、Sudhakara Reddy Seelam、Taisun Kim

  DOI：10.1016/j.tetlet.2010.03.073

  日期：2010.5

  We report the new water-soluble aminocalix[4]arene hosts 1 and 2 with deep hydrophobic cavity facilitating hydrophobic mouth and hydrophilic mouth, respectively. The H-1 NMR titrations revealed that host 1 shows high selectivity for neutral guests 9 and 10, with log K of 4.2 and 4.6, respectively. The host 2 shows log K of 4.9 for binding with guest 15. Moreover, the binding ability of the host 2 for guest 14 is stronger by a factor of 1000 than that of the host 1. (C) 2010 Elsevier Ltd. All rights reserved.