1,3-Bis-(4-bromo-phenyl)-3-trimethylsilanyloxy-butan-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,3-Bis-(4-bromo-phenyl)-3-trimethylsilanyloxy-butan-1-one
• 英文别名: 1,3-Bis(4-bromophenyl)-3-trimethylsilyloxybutan-1-one
• 化学式: C₁₉H₂₂Br₂O₂Si
• 分子量: 470.276
• InChiKey: QYLFNEGSHLSHEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.55
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(4-bromophenyl)-1-(trimethylsilyloxy)ethylene 在 indium(III) chloride 水 作用下， 反应 1.0h， 以75%的产率得到1,3-Bis-(4-bromo-phenyl)-3-trimethylsilanyloxy-butan-1-one
  参考文献：
  名称：

  The indium(III) chloride-catalysed hydrolysis and in situ Mukaiyama-type reaction of arylmethyl ketone derived silyl enol ethers under solvent-free conditions

  摘要：

  Treatment of trimethylsilyl enol ethers of arylmethyl ketones with catalytic amounts of indium(111) chloride under solvent-free conditions leads to a remarkably efficient process of in situ hydrolysis and Mukaiyama-type addition to the resulting ketones. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01350-9

文献信息

• The indium(III) chloride-catalysed hydrolysis and in situ Mukaiyama-type reaction of arylmethyl ketone derived silyl enol ethers under solvent-free conditions
  作者：Sirirat Chancharunee、Patrick Perlmutter、Maya Statton

  DOI：10.1016/s0040-4039(03)01350-9

  日期：2003.7

  Treatment of trimethylsilyl enol ethers of arylmethyl ketones with catalytic amounts of indium(111) chloride under solvent-free conditions leads to a remarkably efficient process of in situ hydrolysis and Mukaiyama-type addition to the resulting ketones. (C) 2003 Elsevier Ltd. All rights reserved.