D-2'-methyltyrosine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-2'-methyltyrosine
• 英文别名: (2R)-2-azaniumyl-3-(4-hydroxy-2-methylphenyl)propanoate
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: AXEOMQHKTSGLGS-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-羟基-1,2,3,4-四氢异喹啉-3-羧酸 在 palladium on activated charcoal 氢气 作用下， 以 溶剂黄146 为溶剂， 60.0 ℃ 、506.62 kPa 条件下， 反应 24.0h， 生成 L-2'-methyltyrosine 、 D-2'-methyltyrosine
  参考文献：
  名称：

  Synthesis and in vitro opioid activity profiles of DALDA analogues

  摘要：

  The tetrapeptide DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) is a polar and selective mu agonist showing poor penetration of the placental and blood-brain barriers. In an effort to enhance the potency of DALDA, analogues containing 2',6'-dimethyltyrosine (Dmt), N,2',6'-trimethyltyrosine (Tmt), 2'-methyltyrosine (Mmt) or 2'-hydroxy,6'-methyltyrosine (Hmt) in place of Tyr(1), or Om or alpha,gamma -diaminobutyric acid (A(2)bu) in place of Lys(4), were synthesized. All compounds displayed high mu receptor selectivity in the rat and guinea pig brain membrane binding assays and most of them were more potent mu agonists than DALDA in the mu receptor-representative guinea pig ileum assay, with [Dmt(1)]DALDA showing the highest potency. Because of its extraordinary mu agonist potency, high mu selectivity, polar character (charge of 3+) and metabolic stability, [Dmt(1)]DALDA has potential for use in obstetrical or peripheral analgesia. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)01171-5

文献信息

• METHOD FOR PRODUCING BETA-AMINO ACID
  申请人：Hidesaki Tomonori

  公开号：US20100221793A1

  公开（公告）日：2010-09-02

  Disclosed is a method for producing a β-amino acid comprising a step of synthesizing a β-amino acid from an α-amino acid in the presence of an amino acid aminomutase. In this method, a β-amino acid is precipitated as a solid in the reaction solution.

  公开了一种制备β-氨基酸的方法，其中包括在存在氨基酸氨基重排酶的情况下，从α-氨基酸合成β-氨基酸的步骤。在该方法中，β-氨基酸在反应溶液中以固体的形式沉淀。
• Enkephalin analogs
  申请人：G.D. Searle & Co.

  公开号：EP0136720A2

  公开（公告）日：1985-04-10

  The invention relates to novel enkephalin analogs of the formula: which are useful as analgesic agents.

  本发明涉及式如下的新型脑啡肽类似物： 可用作镇痛剂。
• METHOD FOR PRODUCING -AMINO ACID
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2216410A1

  公开（公告）日：2010-08-11

  Disclosed is a method for producing a β-amino acid comprising a step of synthesizing a β-amino acid from an α-amino acid in the presence of an amino acid aminomutase. In this method, a β-amino acid is precipitated as a solid in the reaction solution.

  本发明公开了一种生产β-氨基酸的方法，该方法包括在氨基酸氨化酶存在下由α-氨基酸合成β-氨基酸的步骤。在该方法中，β-氨基酸在反应溶液中沉淀为固体。
• EP0932674A4
  申请人：——

  公开号：EP0932674A4

  公开（公告）日：2002-01-30
• A NOVEL MAMMALIAN GENE, bcl-w, BELONGS TO THE bcl-2 FAMILY OF APOPTOSIS-CONTROLLING GENES
  申请人：Amrad Operations Pty.,Ltd.

  公开号：EP0932674A1

  公开（公告）日：1999-08-04