3-[4-(2-amino-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazol-4-yl)-1H-pyrazol-3-yl]phenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[4-(2-amino-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazol-4-yl)-1H-pyrazol-3-yl]phenol
• 英文别名: 3-[4-(2-amino-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-4-yl)-1H-pyrazol-5-yl]phenol
• 化学式: C₁₈H₁₅N₇O
• 分子量: 345.4
• InChiKey: DIAGFJRVICBLFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US10376495B2

  公开（公告）日：2019-08-13

  Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.

  本文描述了用于调节 G-CSF 受体的化合物。这些化合物可作为 G-CSF 的激动剂、拮抗剂和/或混合或部分激动剂/拮抗剂。本文还提供了通过施用本文详述的化合物来治疗包括神经退行性疾病在内的疾病的方法。
• SMALL MOLECULES THAT MIMIC OR ANTAGONIZE ACTIONS OF GRANULOCYTE COLONY-STIMULATING-FACTOR (G-CSF)
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US20180177763A1

  公开（公告）日：2018-06-28

  Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.