N-(1-(2,3-di-tetradecyloxy)-propyloxycarbonylmethyl)-N,N,N-trimethylammonium-methylsulphate | 187828-24-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(1-(2,3-di-tetradecyloxy)-propyloxycarbonylmethyl)-N,N,N-trimethylammonium-methylsulphate
• 英文别名: [2-[2,3-Di(tetradecoxy)propoxy]-2-oxoethyl]-trimethylazanium;methyl sulfate；[2-[2,3-di(tetradecoxy)propoxy]-2-oxoethyl]-trimethylazanium;methyl sulfate
• CAS: 187828-24-6
• 化学式: CH₃O₄S*C₃₆H₇₄NO₄
• 分子量: 696.086
• InChiKey: CQURJBLARUKRPX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  9.13
• 重原子数：
  47
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  硫酸二甲酯 、 N-(1-(2,3-di-tetradecyloxy)-propyloxycarbonylmethyl)-N,N-dimethylamine 以 丙酮 为溶剂， 反应 2.0h， 以40%的产率得到N-(1-(2,3-di-tetradecyloxy)-propyloxycarbonylmethyl)-N,N,N-trimethylammonium-methylsulphate
  参考文献：
  名称：

  Novel cationic amphiphiles

  摘要：

  一种用于促进生物活性分子进入细胞的阳离子两性分子具有结构A-F-D，其中A是脂质锚，D是头基，F是具有所述结构的间隔基团。一种促进生物活性分子进入细胞的方法包括制备包含具有结构A-F-D的阳离子两性分子的脂质混合物，通过将脂质混合物与生物活性分子接触来制备脂质复合物；并将脂质复合物与细胞接触，从而促进生物活性分子进入细胞。

  公开号：

  US20030229037A1

文献信息

• CATIONIC AMPHIPHILES FOR USE IN NUCLEIC ACID TRANSFECTION
  申请人：Roche Diagnostics Corporation

  公开号：EP1261620A2

  公开（公告）日：2002-12-04
• [EN] NOVEL CATIONIC AMPHIPHILES<br/>[FR] NOUVEAUX AMPHIPHILES CATIONIQUES
  申请人：ROCHE DIAGNOSTICS CORP

  公开号：WO2001057064A2

  公开（公告）日：2001-08-09

  A cationic amphiphile for facilitating transport of a biologically active molecule into a cell has the structure A-F-D, in which A is a lipid anchor, D is a head group, and F is a spacer group having the structure described herein. A method for facilitating transport of a biologically active molecule into a cell comprises preparing a lipid mixture comprising a cationic amphiphile having structure A-F-D-, preparing a lipoplex by contacting the lipid mixture with a biologically active molecule; and contacting the lipoplex with a cell, thereby facilitating transport of the biologically active molecule into the cell.
• Novel cationic amphiphiles
  申请人：——

  公开号：US20030229037A1

  公开（公告）日：2003-12-11

  A cationic amphiphile for facilitating transport of a biologically active molecule into a cell has the structure A-F-D, in which A is a lipid anchor, D is a head group, and F is a spacer group having the structure described herein. A method for facilitating transport of a biologically active molecule into a cell comprises preparing a lipid mixture comprising a cationic amphiphile having structure A-F-D, preparing a lipoplex by contacting the lipid mixture with a biologically active molecule; and contacting the lipoplex with a cell, thereby facilitating transport of the biologically active molecule into the cell.

  一种用于促进生物活性分子进入细胞的阳离子两性分子具有结构A-F-D，其中A是脂质锚，D是头基，F是具有所述结构的间隔基团。一种促进生物活性分子进入细胞的方法包括制备包含具有结构A-F-D的阳离子两性分子的脂质混合物，通过将脂质混合物与生物活性分子接触来制备脂质复合物；并将脂质复合物与细胞接触，从而促进生物活性分子进入细胞。