5-methoxy-1-(4-methylphenyl)sulfonyl-2H-quinoline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-methoxy-1-(4-methylphenyl)sulfonyl-2H-quinoline
• 化学式: C₁₇H₁₇NO₃S
• 分子量: 315.393
• InChiKey: JYHDIGHDLSXQRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-tosyl-m-anisidine 在 titanium(IV) isopropylate 、 四氯化钛 、 potassium carbonate 、 苯硫酚 、 间氯过氧苯甲酸 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 5-methoxy-1-(4-methylphenyl)sulfonyl-2H-quinoline
  参考文献：
  名称：

  Stereoselective syntheses of substituted pterocarpans with anti-HIV activity, and 5-aza-/5-thia-pterocarpan and 2-aryl-2,3-dihydrobenzofuran analogues

  摘要：

  Oxygenated pterocarpans and 5-azapterocarpans are prepared utilizing Lewis acid-promoted reactions of 2-alkoxy-1,4-benzoquinones with 2H-chromenes and N-tosyl-3,2-dihydroquinolines, respectively. Similarly, benzannulated analogues are prepared via reactions of 5-alkoxy-1,4-naphthoquinones with chromenes, and related 2-aryl-2,3-dihydrobenzofurans result from reactions of styrenes with the quinones. Syntheses of 5-thiapterocarpans are also described utilizing Pd(0)-coupling of o-chloromercuriophenols with 2H-chromenes. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0968-0896(96)00192-7

文献信息

• Cycloaddition reactions of 1,4-benzoquinone mono- and bisimides with styrenyl systems: New syntheses of nitrogen substituted azapterocarpans, pterocarpans, 2-aryl-2,3-dihydroindoles and -dihydrobenzofurans
  作者：Thomas A. Engler、Kenneth O. Lynch、Wenying Chai、Steven P. Meduna

  DOI：10.1016/0040-4039(95)00375-m

  日期：1995.4

  Lewis acid-promoted reactions of 1,4-benzoquinones and 1,4-benzoquinone bis- and monoimides with various 2H-chromenes, N-tosyl-1,2-dihydroquinolines and styrenes regio- and stereoselectively produce the title compounds in good yields.

  1，4-苯醌，1，4-苯醌双和单酰亚胺与各种2 H-色烯，N-甲苯磺酰基-1,2-二氢喹啉和苯乙烯的路易斯酸促进反应，区域和立体选择性地产生标题化合物，收率高。
• Development of Isomerization and Cycloisomerization with Use of a Ruthenium Hydride with <i>N</i>-Heterocyclic Carbene and Its Application to the Synthesis of Heterocycles
  作者：Mitsuhiro Arisawa、Yukiyoshi Terada、Kazuyuki Takahashi、Masako Nakagawa、Atsushi Nishida

  DOI：10.1021/jo060308u

  日期：2006.5.1

  ruthenium hydride complex with N-heterocyclic carbene (NHC) ligand was efficiently generated from the reaction of a second-generation Grubbs ruthenium catalyst with vinyloxytrimethylsilane and unambiguously characterized. This ruthenium hydride complex showed high catalytic activity for the selective isomerization of terminal olefin and for the cycloisomerization of 1,6-dienes. These reactions of N-allyl-o-vinylaniline

  第二代Grubbs钌催化剂与乙烯基氧基三甲基硅烷的反应可有效生成具有N-杂环卡宾（NHC）配体的纯氢化钌络合物，并具有明确的特征。该氢化钌络合物对末端烯烃的选择性异构化和1,6-二烯的环异构化显示出高催化活性。的这些反应Ñ -allyl- Ò -vinylaniline导致新的合成方法杂环如吲哚和3-亚甲基-2,3- dihydroindoles，这对于生物活性天然产物有用的合成子。这些程序解决了面向多样性的综合中的一个重要问题。
• Tokuyama, Hidetoshi; Sato, Masashi; Ueda, Toshihiro, Heterocycles, 2001, vol. 54, # 1, p. 105 - 108
  作者：Tokuyama, Hidetoshi、Sato, Masashi、Ueda, Toshihiro、Fukuyama, Tohru

  DOI：——

  日期：——