Mahuannin A

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Mahuannin A
• 英文别名: (1S,5R,6R,13R,21S)-5,13-bis(4-hydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.02,11.03,8.015,20]henicosa-2(11),3(8),9,15,17,19-hexaene-6,9,17,19,21-pentol
• 化学式: C₃₀H₂₄O₁₀
• 分子量: 544.5
• InChiKey: LQRHGTVFFPMWCG-JXCVSLFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  40
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• Composite containing collagen and elastin as a dermal expander and tissue filler
  申请人：Hancock-Jaffe Laboratories, Inc.

  公开号：US10583218B2

  公开（公告）日：2020-03-10

  An injectable composition having dermal filling and tissue expanding activity comprises: (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion; and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen; in other alternatives, the composition can further comprise hyaluronic acid; and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition.

  一种具有真皮填充和组织扩张活性的可注射组合物包括：（1）一定量的弹性蛋白，当注射到需要真皮填充和组织扩张的受试者体内时，足以实现真皮填充和组织扩张；（2）药学上可接受的载体。该组合物可进一步包含胶原蛋白；在其他替代方案中，该组合物可进一步包含透明质酸；弹性蛋白、胶原蛋白和透明质酸中的一种或多种（如果存在）可进行分子内或分子间交联。不过，即使组合物中含有胶原蛋白或透明质酸，弹性蛋白也是主要填充物。
• JPS58154585A
  申请人：——

  公开号：JPS58154585A

  公开（公告）日：1983-09-14
• COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER
  申请人：Han Bo

  公开号：US20120010146A1

  公开（公告）日：2012-01-12

  An injectable composition having dermal filling and tissue expanding activity comprises (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion, and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen, in other alternatives, the composition can further comprise hyaluronic acid, and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition
• US9248165B2
  申请人：——

  公开号：US9248165B2

  公开（公告）日：2016-02-02
• [EN] COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER<br/>[FR] COMPOSITE CONTENANT DU COLLAGÈNE ET DE L'ÉLASTINE EN TANT QU'EXPANSEUR DERMIQUE ET AGENT DE REMPLISSAGE TISSULAIRE
  申请人：HANCOCK JAFFE LAB INC

  公开号：WO2010053918A1

  公开（公告）日：2010-05-14

  An injectable composition having dermal filling and tissue expanding activity comprises (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion, and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen, in other alternatives, the composition can further comprise hyaluronic acid, and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition