(2R,2'R,3R,3'R)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2R,2'R,3R,3'R)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol
• 英文别名: (2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
• 化学式: C₃₀H₂₆O₁₂
• 分子量: 578.5
• InChiKey: XFZJEEAOWLFHDH-ATEOAPGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  42
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  221
• 氢给体数：
  10
• 氢受体数：
  12

文献信息

• INHIBITION OF THE FORMATION OF AGEs
  申请人：Abdul-Malak Nabil

  公开号：US20100316743A1

  公开（公告）日：2010-12-16

  The present invention relates to the use of an active substance that promotes the inhibition of the formation of AGEs, for preparing a composition to prevent and/or combat the reduction in elastic and plastic properties of tissues, and in particular of the skin, for inhibiting the formation of AGEs, or for preventing and/or combating glycation of proteins in the skin. The invention also relates to a method of screening such active substances.

  本发明涉及使用促进抑制AGEs形成的活性物质，用于制备一种用于预防和/或对抗组织，特别是皮肤的弹性和塑性特性降低的组合物，用于抑制AGEs的形成，或用于预防和/或对抗皮肤中蛋白质的糖基化。本发明还涉及一种筛选此类活性物质的方法。
• Compositions and methods for the prevention and treatment of circulatory conditions
  申请人：Lau T. David

  公开号：US20070037756A1

  公开（公告）日：2007-02-15

  The present invention relates to compositions and the prevention and treatment of circulatory conditions. In one embodiment, the present invention contemplates a compositions comprising anti-platelet aggregating activity. In another embodiment, the present invention contemplates methods to prevent or treat vascular or cardiovascular diseases. In another embodiment, the present invention relates to a method to prevent or treat cardiovascular disease by administering a glycerol saccharide derivative, an arylpolyphenol, a saccharide substituted with an arylpolyphenol, or a steroid substituted with an arylpolyphenol capable of reducing platelet aggregation. In one embodiment, the invention relates to a method of using the compounds capable of reducing platelet aggregation in order to prevent the recurrence of a heart attack by administration of the compounds to a subject after the subject has experienced a heart attack.

  本发明涉及组合物及其在循环疾病的预防和治疗中的应用。在一种实施例中，本发明涉及一种包含抗血小板聚集活性的组合物。在另一种实施例中，本发明涉及预防或治疗血管或心血管疾病的方法。在另一种实施例中，本发明涉及通过给予一种能够减少血小板聚集的甘油糖衍生物、芳基多酚、被芳基多酚取代的糖或被芳基多酚取代的类固醇来预防或治疗心血管疾病的方法。在一种实施例中，本发明涉及使用能够减少血小板聚集的化合物的方法，以通过给予化合物来预防心脏病发作的再次发生，该化合物在主体经历心脏病发作后给予。
• Xanthone-rich plant extracts or compounds therefrom for modulating diseases of the central nervous system and related disorders
  申请人：Deakin University

  公开号：US10568862B2

  公开（公告）日：2020-02-25

  The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.

  本发明涉及一种治疗和/或预防中枢神经系统疾病或紊乱的方法，包括向需要的哺乳动物施用有效量的富含黄酮的植物提取物或从富含黄酮的植物提取物衍生的化合物。 本发明还涉及富含黄酮的植物提取物或由富含黄酮的植物提取物衍生的化合物在制备治疗和/或预防中枢神经系统疾病或紊乱的药物中的用途，以及富含黄酮的植物提取物或由富含黄酮的植物提取物衍生的化合物在治疗和/或预防中枢神经系统疾病或紊乱中的用途。
• XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING DISEASES OF THE CENTRAL NERVOUS SYSTEM AND RELATED DISORDERS
  申请人：Deakin University

  公开号：US20160367521A1

  公开（公告）日：2016-12-22

  The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.
• [EN] INHIBITION OF AGE FORMATION<br/>[FR] INHIBITION DE LA FORMATION DES AGES.
  申请人：BASF BEAUTY CARE SOLUTIONS F

  公开号：WO2009007411A2

  公开（公告）日：2009-01-15

  La présente invention concerne l'utilisation d'une substance active favorisant l'inhibition de la formation des AGEs, pour la préparation d'une composition pour prévenir et/ou lutter contre la diminution des propriétés élastiques et plastiques des tissus, et en particulier de la peau, pour inhiber la formation des AGEs, ou pour prévenir et/ou lutter contre la glycation des protéines au niveau cutané. L'invention concerne également une méthode de criblage de telles substances actives.