4-methoxy-1-methyl-3-(phenylsulfonyl)pyridin-2(1H)-one | 870854-85-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-1-methyl-3-(phenylsulfonyl)pyridin-2(1H)-one
• 英文别名: 3-(Benzenesulfonyl)-4-methoxy-1-methylpyridin-2-one
• CAS: 870854-85-6
• 化学式: C₁₃H₁₃NO₄S
• 分子量: 279.317
• InChiKey: ZIGYBKRQHDZFQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methoxy-1-methyl-3-(phenylsulfonyl)pyridin-2(1H)-one 在 sodium dithionite 、 四丁基碘化铵 、 碳酸氢钠 作用下， 以 水 、 甲苯 为溶剂， 以93%的产率得到4-甲氧基-1-甲基吡啶-2-酮
  参考文献：
  名称：

  A practical procedure for the selective N-alkylation of 4-alkoxy-2-pyridones and its use in a sulfone-mediated synthesis of N-methyl-4-methoxy-2-pyridone

  摘要：

  It has been found that selective N-alkylation of 4-alkoxy-2-pyridones can be achieved under anhydrous, mild conditions with tetrabutylammonium iodide and potassium tert-butoxide being employed as the catalyst and the base, respectively. The procedure was applied to the preparation of 4-methoxy-l-methyl-2-pyridone, a valuable building block for heterocycle synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.09.095
• 作为产物：
  描述：

  苯磺酰乙腈 在 potassium tert-butylate 、 四丁基碘化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 7.25h， 生成 4-methoxy-1-methyl-3-(phenylsulfonyl)pyridin-2(1H)-one
  参考文献：
  名称：

  A practical procedure for the selective N-alkylation of 4-alkoxy-2-pyridones and its use in a sulfone-mediated synthesis of N-methyl-4-methoxy-2-pyridone

  摘要：

  It has been found that selective N-alkylation of 4-alkoxy-2-pyridones can be achieved under anhydrous, mild conditions with tetrabutylammonium iodide and potassium tert-butoxide being employed as the catalyst and the base, respectively. The procedure was applied to the preparation of 4-methoxy-l-methyl-2-pyridone, a valuable building block for heterocycle synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.09.095

文献信息

• A practical procedure for the selective N-alkylation of 4-alkoxy-2-pyridones and its use in a sulfone-mediated synthesis of N-methyl-4-methoxy-2-pyridone
  作者：David Conreaux、Emmanuel Bossharth、Nuno Monteiro、Philippe Desbordes、Geneviève Balme

  DOI：10.1016/j.tetlet.2005.09.095

  日期：2005.11

  It has been found that selective N-alkylation of 4-alkoxy-2-pyridones can be achieved under anhydrous, mild conditions with tetrabutylammonium iodide and potassium tert-butoxide being employed as the catalyst and the base, respectively. The procedure was applied to the preparation of 4-methoxy-l-methyl-2-pyridone, a valuable building block for heterocycle synthesis. (c) 2005 Elsevier Ltd. All rights reserved.