5-[2-[(2E)-2-[1-(3,4-dichlorophenyl)ethylidene]hydrazinyl]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[2-[(2E)-2-[1-(3,4-dichlorophenyl)ethylidene]hydrazinyl]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-amine
• 化学式: C₁₅H₁₃Cl₂N₅S₂
• 分子量: 398.3
• InChiKey: HSSQXZIYEPIOAX-QPSGOUHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Inhibitors of MALT1-proteolytic activity and uses thereof
  申请人：VIB VZW

  公开号：EP2222326B1

  公开（公告）日：2012-04-18
• GANGLIOSIDE BIOSYNTHESIS MODULATORS
  申请人：CRAWFORD Brett E.

  公开号：US20100248365A1

  公开（公告）日：2010-09-30

  Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation.
• INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF
  申请人：Beyaert Rudi

  公开号：US20110021548A1

  公开（公告）日：2011-01-27

  The present invention relates to inhibitors of MALT1 proteolytic and/or autoproteolytic activity. More specifically, it relates to compounds such as, but not limited to peptide derivates such as Z-LSSR-CHO (see SEQ ID NO:1), Z-LSSR-CMK (see SEQ ID NO:1), Z-GASR-CHO (see SEQ ID NO:2), and Z-GASR-CMK (see SEQ ID NO:2), and small compounds such as 5-[5-(3-chloro-4-methylphenyl)-2-furyl]methylene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione and variants thereof, and the use of those compounds for the preparation of a medicament. The invention relates further to a method to screen for inhibitors of the MALT1 proteolytic and/or autoproteolytic activity.