12-methylstearic acid | 87259-17-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-methylstearic acid
• 英文别名: (+/-)-12-methyl-octadecanoic acid；(+/-)-12-Methyl-octadecansaeure；12-Methyloctadecanoic acid
• CAS: 87259-17-4
• 化学式: C₁₉H₃₈O₂
• 分子量: 298.51
• InChiKey: MEBDGIUGSQZVMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  12-methylstearic acid 在 氯化亚砜 作用下， 生成 (+/-)-12-methyl-octadecanoic acid amide
  参考文献：
  名称：

  The Active 12-Methyloctadecanoic Acids

  摘要：

  DOI：

  10.1021/jo01088a025
• 作为产物：
  描述：

  8-oxooctadecanoic acid 生成 12-methylstearic acid
  参考文献：
  名称：

  MENGER, F. M.;WOOD, M. G. (JR);RICHARDSON, S.;ZHOU, Q.;ELRINGTON, A. R.;S+, J. AMER. CHEM. SOC., 110,(1988) N 20, C. 6797-6803

  摘要：

  DOI：

文献信息

• Oleogel compositions for retinal drug delivery
  申请人：University of Florida Research Foundation, Inc.

  公开号：US11406594B2

  公开（公告）日：2022-08-09

  In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  在一个方面，本公开涉及在视网膜中延长药物释放的组合物。在另一个方面，本公开提供了包含用于视网膜给药的治疗剂的缓释组合物的制备方法。在其他各方面，本公开提供了通过玻璃体内注射向视网膜递送包含治疗剂的已公开组合物的方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本公开内容的限制。
• BRANCHED-CHAIN FATTY ACIDS. XIII. PREPARATION OF BRANCHED AND NORMAL ACIDS FOR USE IN THE STUDY OF MELTING POINTS OF BINARY MIXTURES. COMPLETION OF THE METHYLOCTADECANOIC ACID SERIES
  作者：JAMES CASON、W. ROBERT WINANS

  DOI：10.1021/jo01147a023

  日期：1950.1
• Weitzel; Wojahn, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1951, vol. 287, p. 296,304,305
  作者：Weitzel、Wojahn

  DOI：——

  日期：——
• Promiscuous Fatty Acyl CoA Ligases Produce Acyl-CoA and Acyl-SNAC Precursors for Polyketide Biosynthesis
  作者：Pooja Arora、Archana Vats、Priti Saxena、Debasisa Mohanty、Rajesh S. Gokhale

  DOI：10.1021/ja052991s

  日期：2005.7.1

  The study of bioactive natural products has undergone rapid advancement with the cloning and sequencing of large number of gene clusters and the concurrent progress to manipulate complex biosynthetic systems in heterologous hosts. The genetic reconstitution necessitates that the heterologous hosts possess substrate pools that could be coordinately supplied for biosynthesis. Polyketide synthases (PKS) utilize acyl-coenzyme A (CoA) precursors and synthesize polyketides by repetitive decarboxylative condensations. Here we show that acyl-CoA ligases, which belong to a large family of acyl-activating enzymes, possess potential to produce varied starter CoA precursors that could be utilized in polyketide biosynthesis. Incidentally, such protein domains have been recognized in several PKS and nonribosomal peptide synthetase gene clusters. Our studies with mycobacterial fatty acyl-CoA ligases (FACLs) show remarkable tolerance to activate a variety of fatty acids that contain modifications at alpha, beta, omega, and omega-nu positions. This substrate flexibility extends further such that these proteins also efficiently utilize N-acetyl cysteamine, the shorter acceptor terminal portion of CoASH, to produce acyl-SNACs. We show that the in situ generated acyl-CoAs and acyl-SNACs could be channeled to types I and -III PKS systems to produce new metabolites. Together, the promiscuous activity of FACL and PKSs provides new opportunities to expand the repertoire of natural products.
• Chain-substituted lipids in monolayer films. A study of molecular packing
  作者：F. M. Menger、M. G. Wood、S. Richardson、Q. Zhou、A. R. Elrington、M. J. Sherrod

  DOI：10.1021/ja00228a032

  日期：1988.9