Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene
作者:Shinpei Murasawa、Katsuya Iuchi、Shinichi Sato、Tomomi Noguchi-Yachide、Mikiko Sodeoka、Tsutomu Yokomatsu、Kosuke Dodo、Yuichi Hashimoto、Hiroshi Aoyama
DOI:10.1016/j.bmc.2012.08.062
日期:2012.11
A structure consisting of substituted hydantoin linked to a 5-(halophenyl)furan-2-yl group via an amide bond was identified as a promising scaffold for development of low-molecular-weight therapeutic agents to treat vascular dysfunction, including ischemia/reperfusion injury. Among the compounds synthesized, 5-(3,5-dichlorophenyl)-N-2,4-dioxo-3-[(pyridin-3-yl)methyl]imidazolidin-1-yl}-2-furamide (17)
由取代的乙内酰脲通过酰胺键与5-(卤代苯基)呋喃-2-基连接的结构被鉴定为开发低分子量治疗剂以治疗血管功能障碍(包括缺血/再灌注损伤)的有前途的支架。在合成的化合物中,5-(3,5-二氯苯基)-N- 2,4-二氧代-3-[(吡啶-3-基)甲基]咪唑啉-1--1-基} -2-呋喃酰胺(17)具有对Ca 2+诱导的线粒体肿胀最有效的抑制活性。描述了这些化合物的结构发展,合成和结构-活性关系。