Tipepidine citrate | 14698-07-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tipepidine citrate
• 英文别名: 3-(dithiophen-2-ylmethylidene)-1-methylpiperidine;2-hydroxypropane-1,2,3-tricarboxylic acid
• CAS: 14698-07-8
• 化学式: C21H25NO7S2
• 分子量: 467.6
• InChiKey: WQOYJMWVNIGIQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  192
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Stabilized solid pharmaceutical preparation containing dextromethorphan, phenylpropanolamine and caffeine
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0631782A1

  公开（公告）日：1995-01-04

  To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may further comprise ibuprofen. The active ingredients may be further stabilized, in combination with the incorporation of the caffeine, by grouping and incorporating separately each or suitably combined plural of the active ingredients into different groups or by minimizing the amount of any reducing sugar such as lactose. The solid pharmaceutical preparation is practically valuable since decomposition of each active ingredient with the lapse of time is remarkably suppressed and the active ingredients are stabilized for a longer period of time.

  为了稳定活性成分，咖啡因被加入到由右美沙芬和苯丙醇胺组成的固体药物制剂中。药物制剂还可进一步包含布洛芬。在掺入咖啡因的同时，还可通过将每种或适当组合的多种活性成分分别分组并掺入不同的组中，或通过尽量减少任何还原糖（如乳糖）的用量，来进一步稳定活性成分。这种固体药物制剂具有很高的实用价值，因为每种有效成分随着时间的推移而分解的现象明显减少，有效成分的稳定时间也更长。
• SOLID PREPARATION CONTAINING SPARINGLY SOLUBLE NSAIDS
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1103258A1

  公开（公告）日：2001-05-30

  A readily absorbable solid composition comprising sparingly soluble NSAIDs of the propionic acid type, a water-soluble polymeric base, and a nonionic surfactant.

  一种易于吸收的固体组合物，由丙酸类难溶性非甾体抗炎药、水溶性聚合物基和非离子表面活性剂组成。
• IBUPROFEN SOLUTIONS FOR CAPSULE-FILLING AND CAPSULE PREPARTIONS
  申请人：Kowa Company, Ltd.

  公开号：EP1321140A1

  公开（公告）日：2003-06-25

  A fill liquid composition for capsules is produced by mixing ibuprofen, polyethylene glycol, water and terpenoid selected from menthol, limonene, borneol, dl-camphor, peppermint oil and so forth, and optionally one or more agents selected from antipyretic analgesic, anti-histamine, antitussive, expectorant, sympathetic nerve stimulant, central stimulant, hypnotic sedative and antiphlogistic, and solubilizing agent, viscous agent, pH adjuster, coloring agent, and the like, in order to exhibit the effects that the prevention of bitterness of ibuprofen and the quick-activeness of ibuprofen are consistently achieved.

  将布洛芬、聚乙二醇、水和选自薄荷醇、柠檬烯、龙脑、樟脑、薄荷油等的萜类化合物，以及可选的一种或多种选自解热镇痛剂、抗组胺剂、止咳剂、祛痰剂、交感神经刺激剂、中枢兴奋剂、催眠镇静剂和解热镇痛剂的药剂，以及增溶剂、粘稠剂、pH 值调节剂、着色剂等混合，制成一种胶囊填充液体组合物、以及增溶剂、粘稠剂、pH 值调节剂、着色剂等，以表现出布洛芬的防苦味效果和布洛芬的速效性。
• DRUG PREPARATIONS
  申请人：SSP Co., Ltd.

  公开号：EP1391200A1

  公开（公告）日：2004-02-25

  Drug preparations characterized by containing fudosteine and an antitussive. These preparations are drugs to be used for common cold, etc. which have improved antitussive and sputum-removal effects.

  药物制剂，其特点是含有夫多斯汀和一种止咳药。这些制剂是用于治疗普通感冒等的药物，具有更好的止咳和化痰效果。
• MEDICINAL COMPOSITIONS
  申请人：SSP Co., Ltd.

  公开号：EP1391201A1

  公开（公告）日：2004-02-25

  Medicinal compositions characterized by containing fudosteine and an antipyretic/analgesic. These medicinal compositions are medicinal compositions to be used for common cold, etc. which have improved sputum-removal and antiinflammatory effects.

  药用复方制剂，其特点是含有呋喃妥因和解热镇痛药。这些药剂组合物是用于普通感冒等的药剂组合物，具有更好的化痰和消炎效果。