3-<4-(Dimethoxymethyl)phenoxy>-4,5-dimethoxybenzaldehyde | 152035-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-<4-(Dimethoxymethyl)phenoxy>-4,5-dimethoxybenzaldehyde
• 英文别名: 3-[4-(Dimethoxymethyl)phenoxy]-4,5-dimethoxybenzaldehyde
• CAS: 152035-71-7
• 化学式: C₁₈H₂₀O₆
• 分子量: 332.353
• InChiKey: BPMLFTHPOXONPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-methoxycarbonyl-5-isoxazolylmethyl-triphenylphosphonium bromide 、 3-<4-(Dimethoxymethyl)phenoxy>-4,5-dimethoxybenzaldehyde 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (Z)-3-(Methoxycarbonyl)-5-<2-<4,5-dimethoxy-3-<4-(dimethoxymethyl)phenoxy>phenyl>-1-ethenyl>isoxazole 、 (E)-3-(Methoxycarbonyl)-5-<2-<4,5-dimethoxy-3-<4-(dimethoxymethyl)phenoxy>phenyl>-1-ethenyl>isoxazole
  参考文献：
  名称：

  Synthesis and revised structure of garuganin III

  摘要：

  Macrocyclic beta-methoxy enones 6 and 1-3, i.e., garuganin III and its constitutional and stereoisomers, were synthesized using an isoxazole synthon for the introduction of the beta-methoxy enone function. Ring closure was accomplished by an intramolecular Wittig reaction. Compound 6 rather than 1, as suggested previously, was found to have an H-1-NMR spectrum and a mp identical to those of garuganin III.

  DOI：

  10.1021/jo00076a036
• 作为产物：
  描述：

  3,4-二甲氧基-5-羟基苯甲酸甲酯 在 manganese(IV) oxide 、 lithium aluminium tetrahydride 、 potassium carbonate 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.5h， 生成 3-<4-(Dimethoxymethyl)phenoxy>-4,5-dimethoxybenzaldehyde
  参考文献：
  名称：

  Synthesis and revised structure of garuganin III

  摘要：

  Macrocyclic beta-methoxy enones 6 and 1-3, i.e., garuganin III and its constitutional and stereoisomers, were synthesized using an isoxazole synthon for the introduction of the beta-methoxy enone function. Ring closure was accomplished by an intramolecular Wittig reaction. Compound 6 rather than 1, as suggested previously, was found to have an H-1-NMR spectrum and a mp identical to those of garuganin III.

  DOI：

  10.1021/jo00076a036

文献信息

• Synthesis and revised structure of garuganin III
  作者：Gyorgy M. Keseru、Zoltan Dienes、Mihaly Nogradi、Maria Kajtar-Peredy

  DOI：10.1021/jo00076a036

  日期：1993.11

  Macrocyclic beta-methoxy enones 6 and 1-3, i.e., garuganin III and its constitutional and stereoisomers, were synthesized using an isoxazole synthon for the introduction of the beta-methoxy enone function. Ring closure was accomplished by an intramolecular Wittig reaction. Compound 6 rather than 1, as suggested previously, was found to have an H-1-NMR spectrum and a mp identical to those of garuganin III.