2-Aziridin-1-yl-phenol | 799818-04-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Aziridin-1-yl-phenol
• 英文别名: 2-(Aziridin-1-yl)phenol；2-(aziridin-1-yl)phenol
• CAS: 799818-04-5
• 化学式: C₈H₉NO
• 分子量: 135.166
• InChiKey: ZWYXPKBYGODXRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  23.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-二溴乙烷 、 2-氨基苯酚 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 8.0h， 生成 3,4-二氢-2H-1,4-苯并噁嗪 、 2-Aziridin-1-yl-phenol
  参考文献：
  名称：

  Condensation of Aniline and o-Hydroxyaniline with 1,2-Dibromoethane

  摘要：

  DOI：

  10.1023/b:rujo.0000034957.86085.c2

文献信息

• Substituted phenyl aziridine precursor analogs for inhibiting androgen-independent prostate cancer cell growth
  申请人：Northwestern University

  公开号：US10799475B2

  公开（公告）日：2020-10-13

  Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.

  公开了调节一种或多种类固醇受体活性的方法和药物组合物。这些方法和药物组合物通常包括一种或多种取代苯基氮丙啶前体、各自的氮丙啶、其类似物、其衍生物或其药学上可接受的盐，如 CpdA。这些方法和组合物可用于治疗与糖皮质激素受体活性、雄激素受体活性或两者相关的疾病、失调和病症，如癌症、寻常痤疮和脱发。
• Use of carboxy compounds such as 2(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride as anti-inflammatory agents
  申请人：——

  公开号：US20030055030A1

  公开（公告）日：2003-03-20

  The present invention relates to the use of specific carboxy compounds, more specifically to the use of 2(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride, in the treatment of inflammatory diseases. Part of the invention is also a composition, preferably a pharmaceutical composition, comprising as active ingredient at least 2 (4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride together with (pharmaceutically) acceptable excipients.

  本发明涉及特定羧基化合物在治疗炎症疾病中的应用，更具体地说，涉及 2（4-乙酰氧基苯基）-2-氯-N-甲基乙基氯化铵在治疗炎症疾病中的应用。本发明还包括一种组合物，最好是一种药物组合物，其活性成分至少包括 2（4-乙酰氧基苯基）-2-氯-N-甲基乙基氯化铵和（药学上）可接受的赋形剂。
• USE OF CARBOXY COMPOUNDS SUCH AS 2(4-ACETOXYPHENYL)-2-CHLORO-N-METHYL-ETHYLAMMONIUM CHLORIDE AS ANTI-INFLAMMATORY AGENTS
  申请人：Vlaams Interuniversitair Instituut voor Biotechnologie vzw.

  公开号：EP1239850A1

  公开（公告）日：2002-09-18
• Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities
  申请人：Budunova Irina

  公开号：US20090156672A1

  公开（公告）日：2009-06-18

  Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.
• Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth
  申请人：Northwestern University

  公开号：US20140045938A1

  公开（公告）日：2014-02-13

  Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.