N-Boc-diisopropylamine | 105678-27-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Boc-diisopropylamine
• 英文别名: tert-butyl N,N'-diisopropylimidocarbamate；Tert-butyl N,N-diisopropylcarbamate；tert-butyl N,N-di(propan-2-yl)carbamate
• CAS: 105678-27-1
• 化学式: C₁₁H₂₃NO₂
• mdl: MFCD24393418
• 分子量: 201.309
• InChiKey: HNURUDICJPOGGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid 、 N-Boc-diisopropylamine 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 以37%的产率得到tert-butyl 5-bromo-6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylate
  参考文献：
  名称：

  [EN] THIENOPYRROLES AS ANTIVIRAL AGENTS
  [FR] THIENOPYRROLES UTILISES COMME AGENTS ANTIVIRAUX

  摘要：

  本发明涉及式(I)的噻吡咯烷化合物；其中A、B、Y、Ar、n、Z和X1如本文所定义，并且其药学上可接受的盐，在预防和治疗丙型肝炎感染中有用。

  公开号：

  WO2005023819A1
• 作为产物：
  描述：

  2-甲基-2-丙基2-吡啶基碳酸酯 、 二异丙胺 以 乙腈 为溶剂， 反应 60.0h， 以86%的产率得到N-Boc-diisopropylamine
  参考文献：
  名称：

  用于胺和氨基酸的丁氧基羰基化和苄氧基羰基化的新型氨基保护试剂

  摘要：

  已经开发了用于胺和氨基酸的叔丁氧基羰基化和苄氧基羰基化的新型氨基保护试剂。叔丁基 2-吡啶基碳酸酯和叔丁基 S-(2-吡啶基) 硫代碳酸酯与各种胺和氨基酸完全反应，以高产率提供 N-Boc 胺和 N-Boc 氨基酸。也发现苄基 2-吡啶基碳酸酯和 O-苄基 S-(2-吡啶基) 硫代碳酸酯在氨基酸的苄氧羰基化中非常有效。

  DOI：

  10.1246/bcsj.58.3570

文献信息

• Modulators of muscarinic receptors
  申请人：Makings R. Lewis

  公开号：US20080015179A1

  公开（公告）日：2008-01-17

  The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

  本发明涉及肌胆碱受体调节剂。本发明还提供包含这种调节剂的组合物，并提供了用于治疗肌胆碱受体介导疾病的方法。
• Synthesis of Amide Enol Carbamates and Carbonates through Cu(OTf)₂-Catalyzed Reactions of Ynamides with <i>t</i>-Butyl Carbamates/Carbonates
  作者：Pan Han、Zhuo-Ya Mao、Ming Li、Chang-Mei Si、Bang-Guo Wei、Guo-Qiang Lin

  DOI：10.1021/acs.joc.9b03512

  日期：2020.4.3

  A highly regioselective approach to access amide enol carbamates and carbonates 5a–5c′, 7a–7h, and 9 was developed through Cu(OTf)2-catalyzed reactions of ynamides 4 with t-butyl carbamates 2 and 8 and t-butyl carbonates 6. Moreover, this strategy was successfully applied to generate amide enol carbamates 11a–11s and 14a–14f from imides 10 and 13 with ynamides through an N-Boc cleavage–addition ring-opening

  甲高度选择性的方法来访问酰胺烯醇氨基甲酸酯和碳酸酯5A -图5c' ，7A - 7H，和9通过铜（OTF）开发2个的ynamides催化的反应4与吨丁基氨基甲酸酯2和8和吨丁基碳酸盐6。此外，该策略已成功应用于从酰亚胺10和13与乙酰胺通过酰胺生成酰胺烯醇氨基甲酸酯11a - 11s和14a - 14f。N -Boc裂解-加成开环过程。一系列取代基适合该转化，并且以中等至良好的产率获得了所需的酰胺烯醇氨基甲酸酯和碳酸酯。
• POSITIVE PHOTOSENSITIVE RESIN COMPOSITION, POSITIVE PHOTOSENSITIVE DRY FILM, METHOD FOR PRODUCING POSITIVE PHOTOSENSITIVE DRY FILM, PATTERNING PROCESS, METHOD FOR FORMING CURED FILM, INTERLAYER INSULATION FILM, SURFACE PROTECTIVE FILM, AND ELECTRONIC COMPONENT
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3951498A1

  公开（公告）日：2022-02-09

  The present invention is a positive photosensitive resin composition including: (A) an alkali-soluble resin containing at least one or more structures selected from a polyimide structure, a polybenzoxazole structure, a polyamide-imide structure, and a precursor structure thereof; (B) a crosslinkable polymer compound containing a structural unit represented by the following general formula (1) and having a group crosslinked with the component (A); and (C) a compound having a quinonediazide structure for serving as a photosensitizer to generate an acid by light and increase a dissolution speed to an alkaline aqueous solution. An object of the present invention is to provide a positive photosensitive resin composition and a positive photosensitive dry film that enable formation of a fine pattern and high resolution, have excellent mechanical characteristics even when cured at low temperatures, and have no degradation in adhesive force between before and after a high temperature and high humidity test.

  本发明是一种正性光敏树脂组合物，包括(A)一种碱溶性树脂，含有至少一种或多种选自聚酰亚胺结构、聚苯并恶唑结构、聚酰胺-酰亚胺结构及其前体结构的结构；(B)一种可交联聚合物化合物，含有由下式(1)表示的结构单元，并具有与组分(A)交联的基团；以及(C)一种具有喹酮噻嗪结构的化合物，用作光敏剂，通过光产生酸，并提高对碱性水溶液的溶解速度。本发明的目的是提供一种正感光树脂组合物和一种正感光干膜，这种组合物和干膜能形成精细的图案和高分辨率，即使在低温下固化也具有优良的机械特性，而且在高温高湿试验前后粘合力不会下降。
• Photosensitive resin composition, protective film, and liquid crystal display element
  申请人：Chi Mei Corporation

  公开号：US10162260B2

  公开（公告）日：2018-12-25

  The invention shows a photosensitive resin composition which can be used in protective film and liquid crystal display element and provides good transparency and high chemical resistance. The composition includes a complex resin (A), an o-naphthoquinone diazide sulfonate (B), and a solvent (C). The complex resin (A) includes a main chain and a side chain. The main chain includes a repeating unit derived from siloxane (meth)acrylate based monomer (a1-2). The side chain includes a repeating unit derived from siloxane based monomer (a2), and is bonded to the repeating unit derived from siloxane (meth)acrylate based monomer (a1-2). The complex resin (A) satisfies at least one of the following conditions (I) and (II): Condition (I): the main chain further includes a repeating unit derived from unsaturated monomer (a1-1) including a carboxylic acid or a carboxylic anhydride. Condition (II): the siloxane based monomer (a2) includes a monomer (a2-1) represented by formula (A-4).

  本发明展示了一种光敏树脂组合物，可用于保护膜和液晶显示元件，具有良好的透明性和高耐化学腐蚀性。该组合物包括复合树脂（A）、邻萘醌重氮磺酸盐（B）和溶剂（C）。复合树脂（A）包括一条主链和一条侧链。主链包括由硅氧烷（甲基）丙烯酸酯单体（a1-2）衍生的重复单元。侧链包括硅氧烷基单体（a2）衍生的重复单元，并与硅氧烷（甲基）丙烯酸酯基单体（a1-2）衍生的重复单元键合。复合树脂（A）至少满足以下条件（I）和（II）之一： 条件 (I)：主链还包括一个由不饱和单体（a1-1）衍生的重复单元，不饱和单体（a1-1）包括羧酸或羧酸酐。 条件（II）：硅氧烷基单体（a2）包括由式（A-4）表示的单体（a2-1）。
• PYRIDO[2,3-D]PYRIMIDINES USEFUL AS HCV INHIBITORS, AND METHODS FOR THE PREPARATION THEREOF
  申请人：Simmen Kenneth Alan

  公开号：US20090131460A1

  公开（公告）日：2009-05-21

  The present invention relates to the use of pyrido[2,3-d]pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to pyrido-[2,3-d]pyrimidines compounds per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.