2-Chloromethyl-5-methoxy-oxazole-4-carboxylic acid methyl ester | 240116-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Chloromethyl-5-methoxy-oxazole-4-carboxylic acid methyl ester
• 英文别名: Methyl 2-(chloromethyl)-5-methoxy-4-oxazolecarboxylate；methyl 2-(chloromethyl)-5-methoxy-1,3-oxazole-4-carboxylate
• CAS: 240116-10-3
• 化学式: C₇H₈ClNO₄
• 分子量: 205.598
• InChiKey: KXTDZIVMWRZQQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  bis(methoxycarbonyl)(phenyliodinio)methanide 、 氯乙腈 在 dirhodium tetraacetate 作用下， 反应 0.03h， 以61%的产率得到2-Chloromethyl-5-methoxy-oxazole-4-carboxylic acid methyl ester
  参考文献：
  名称：

  RhII-catalyzed cycloadditions of carbomethoxy iodonium ylides

  摘要：

  Carbomethoxy iodonium ylides, generated from methyl acetoacetate and methyl malonate, respectively, are exploited in synthesis of cyclopropanes, cyclopropenes as well as various heterocycles. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01260-1

文献信息

• Synthesis of the enantiopure C15–C26 segment of phorboxazole A and B
  作者：Peter Wolbers、Andrea M. Misske、H. Martin R.%Hoffinann

  DOI：10.1016/s0040-4039(99)00803-5

  日期：1999.6

  Two approaches towards an enantiopure C15-C26 segment of the phorboxazoles starting from the corresponding C20-C26 aldehyde are presented. A variety of functionalized oxazoles have been synthesized via the rhodium(II) acetate catalyzed cycloaddition of dimethyl diazomalonate to substituted nitriles. (C) 1999 Elsevier Science Ltd. All rights reserved.
• RhII-catalyzed cycloadditions of carbomethoxy iodonium ylides
  作者：Christina Batsila、George Kostakis、Lazaros P Hadjiarapoglou

  DOI：10.1016/s0040-4039(02)01260-1

  日期：2002.8

  Carbomethoxy iodonium ylides, generated from methyl acetoacetate and methyl malonate, respectively, are exploited in synthesis of cyclopropanes, cyclopropenes as well as various heterocycles. (C) 2002 Elsevier Science Ltd. All rights reserved.