3-[1-[6-(2,5-Dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazol-5-yl]-meth-(E)-ylidene]-1,3-dihydro-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[1-[6-(2,5-Dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazol-5-yl]-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
• 英文别名: (3E)-3-[[6-(2,5-dimethoxyphenyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl]methylidene]-1H-indol-2-one
• 化学式: C₂₂H₁₉N₃O₃S
• 分子量: 405.477
• InChiKey: KLSFQANGDMDDCW-NTCAYCPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  90.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-吲哚酮 、 6-(2,5-Dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole-5-carbaldehyde 在 哌啶 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 3-[1-[6-(2,5-Dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazol-5-yl]-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
  参考文献：
  名称：

  Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones

  摘要：

  A compound endowed with coanthracyclinic activity should potentiate the antitumor activity of anthracyclines report the synthesis and configuration of a series of substituted while counteracting their cardiodepressant effect. We now the 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones which were tested for both cardiotonic and cytotoxic activity. Several compounds were potent cytotoxic agents and two of them (in particular 3-[6-(2,5-dimethoxyphenyl)-5-imidazo[2,1-b]thiazolylmethylene]-2-indolinone), which showed even cardiotonic activity, are potential coanthracyclinic agents.

  DOI：

  10.1016/s0223-5234(97)82778-x

文献信息

• Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones
  作者：A Andreani、A Locatelli、A Leoni、M Rambaldi、R Morigi、R Bossa、M Chiericozzi、A Fraccari、I Galatulas

  DOI：10.1016/s0223-5234(97)82778-x

  日期：1997.11

  A compound endowed with coanthracyclinic activity should potentiate the antitumor activity of anthracyclines report the synthesis and configuration of a series of substituted while counteracting their cardiodepressant effect. We now the 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones which were tested for both cardiotonic and cytotoxic activity. Several compounds were potent cytotoxic agents and two of them (in particular 3-[6-(2,5-dimethoxyphenyl)-5-imidazo[2,1-b]thiazolylmethylene]-2-indolinone), which showed even cardiotonic activity, are potential coanthracyclinic agents.