(S)-3-{(8S,13R)-8,13-Dihydroxy-13-[(2R,5R,2'R,5'R)-5'-((S)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-tridecyl}-5-methyl-5H-furan-2-one | 158515-36-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-3-{(8S,13R)-8,13-Dihydroxy-13-[(2R,5R,2'R,5'R)-5'-((S)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-tridecyl}-5-methyl-5H-furan-2-one
• 英文别名: (5S)-3-[(8S,13R)-8,13-Dihydroxy-13-[(2R,2a(2)R,5R,5a(2)R)-octahydro-5a(2)-[(1S)-1-hydroxyundecyl][2,2a(2)-bifuran]-5-yl]tridecyl]-5-methyl-2(5H)-furanone；(2S)-4-[(8S,13R)-8,13-dihydroxy-13-[(2R,5R)-5-[(2R,5R)-5-[(1S)-1-hydroxyundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]-2-methyl-2H-furan-5-one
• CAS: 158515-36-7
• 化学式: C₃₇H₆₆O₇
• 分子量: 622.927
• InChiKey: ZKPIIYAYSXXUDC-UXQNAKQRSA-N

反应信息

• 作为反应物：
  描述：

  甲氧基-三氟甲基苯 、 (S)-3-{(8S,13R)-8,13-Dihydroxy-13-[(2R,5R,2'R,5'R)-5'-((S)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-tridecyl}-5-methyl-5H-furan-2-one 在 吡啶 、 4-二甲氨基吡啶 作用下， 反应 4.0h， 生成
  参考文献：
  名称：

  The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba

  摘要：

  A novel acetogenin, asiminocin (1), was isolated by activity-directed fractionation from the stem bark of the paw paw tree, Asimina triloba. By spectral and chemical methods, 1 was identified as (30S)-hydroxy-4-deoxyasimicin. The absolute configuration of 1, along with those of previously reported acetogenins asimin, asiminacin, bullatin, (30S)-bullanin, and (30R) bullanin, was determined by Mosher ester methodology. Compound 1 was highly inhibitory to three human solid tumor cell lines with over a billion times the potency of adriamycin.

  DOI：

  10.1016/0968-0896(95)00155-7