(4S,4aS,6aS,11aS,11bS)-9-Methoxy-2,2,4a-trimethyl-2,3,4,4a,5,6,6a,7,10,11,11a,11b-dodecahydro-1H-benzo[a]fluoren-4-ol | 388567-67-7

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: (4S,4aS,6aS,11aS,11bS)-9-Methoxy-2,2,4a-trimethyl-2,3,4,4a,5,6,6a,7,10,11,11a,11b-dodecahydro-1H-benzo[a]fluoren-4-ol
• CAS: 388567-67-7
• 化学式: C₂₁H₃₂O₂
• 分子量: 316.484
• InChiKey: BJOHREOWCACCGJ-PWIGDYEPSA-N

反应信息

• 作为反应物：
  描述：

  (4S,4aS,6aS,11aS,11bS)-9-Methoxy-2,2,4a-trimethyl-2,3,4,4a,5,6,6a,7,10,11,11a,11b-dodecahydro-1H-benzo[a]fluoren-4-ol 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以61%的产率得到16,16-dimethyl-D-homo-19,B-bisnor-8,10-isotestosterone
  参考文献：
  名称：

  带有顺式融合的B环和C环的类固醇雄激素19，B-双歧类似物的合成

  摘要：

  Reduction by Birch procedure of 3-methoxy-B-nor-8-isoestra-1,3,5(10)-trienes followed by hydrolysis of reaction products furnished 19,B-bisnor-8,10-isoanalogs of steroid androgens. With the use of the correlation NMR spectroscopy a complete assignment of signals in the H-1 and C-13 NMR spectra was performed for two representatives of this steroid group, and their prevailing conformations in solution were established.

  DOI：

  10.1023/a:1012401312741
• 作为产物：
  描述：

  17aβ-hydroxy-16,16-dimethyl-3-methoxy-D-homo-B-norestra-1,3,5(10),8,14-pentaene 在 镍 吡啶 、 氨 、 氢气 、 lithium 作用下， 以 四氢呋喃 、 苯 为溶剂， -60.0~120.0 ℃ 、14.71 MPa 条件下， 反应 8.0h， 生成 (4S,4aS,6aS,11aS,11bS)-9-Methoxy-2,2,4a-trimethyl-2,3,4,4a,5,6,6a,7,10,11,11a,11b-dodecahydro-1H-benzo[a]fluoren-4-ol
  参考文献：
  名称：

  带有顺式融合的B环和C环的类固醇雄激素19，B-双歧类似物的合成

  摘要：

  Reduction by Birch procedure of 3-methoxy-B-nor-8-isoestra-1,3,5(10)-trienes followed by hydrolysis of reaction products furnished 19,B-bisnor-8,10-isoanalogs of steroid androgens. With the use of the correlation NMR spectroscopy a complete assignment of signals in the H-1 and C-13 NMR spectra was performed for two representatives of this steroid group, and their prevailing conformations in solution were established.

  DOI：

  10.1023/a:1012401312741