| 1236850-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1236850-46-6
• 化学式: C₁₀H₁₅N₃O₂
• 分子量: 209.248
• InChiKey: UHWMMERVSMURAZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  三氟甲磺酸酐 、 在 2,4,6-三甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  5-Arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists

  摘要：

  A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor receptor. Formation of CYP-mediated oxidative reactive metabolites previously observed in a related N-3-phenylpyrazinone structure was minimized by incorporation of the additional ring nitrogen found in the triazinones. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.121
• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 生成
  参考文献：
  名称：

  5-Arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists

  摘要：

  A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor receptor. Formation of CYP-mediated oxidative reactive metabolites previously observed in a related N-3-phenylpyrazinone structure was minimized by incorporation of the additional ring nitrogen found in the triazinones. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.121