[3-(4-amino-6-chloro-[1,3,5]triazin-2-yloxy)-2,2-bis-(3,5-bis-decyloxybenzyl)propyl]carbamic acid tert-butyl ester | 414861-06-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-(4-amino-6-chloro-[1,3,5]triazin-2-yloxy)-2,2-bis-(3,5-bis-decyloxybenzyl)propyl]carbamic acid tert-butyl ester
• CAS: 414861-06-6
• 化学式: C₆₅H₁₁₀ClN₅O₇
• 分子量: 1109.07
• InChiKey: FNNPWBPKIUTCLI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  [3-(4-amino-6-chloro-[1,3,5]triazin-2-yloxy)-2,2-bis-(3,5-bis-decyloxybenzyl)propyl]carbamic acid tert-butyl ester 在 盐酸 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 1-(4-amino-6-chloro-[1,3,5]triazin-2-yloxy)-2,2-bis-(3,5-bis-decyloxybenzyl)-3-(4-amino-6-chloro-[1,3,5]triazin-2-ylamino)propane
  参考文献：
  名称：

  Synthetic duplex oligomers: optimizing interstrand affinity through the use of a noncovalent constraint

  摘要：

  The covalent casting of a one-dimensional hydrogen-bonding motif permits the design of oligomers possessing a predetermined duplex mode of aggregation. In this account, studies on the hydrogen bond mediated self-assembly of dimeric duplex oligomers 2 in solution are described. Two-fold self-association in solution is established by H-1 NMR, and the intended mode of assembly is further corroborated via X-ray crystallographic analysis. An increase in interstrand affinity of over three orders of magnitude is observed upon substitution of nitrogen for oxygen in the oligomer backbone, owing to preorganization of the molecular strand in the binding effective conformation as directed by the formation of an internal hydrogen bond. These data provide insight into the structural and interactional features of the oligomers required for high affinity/specificity binding in organic media. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01090-0
• 作为产物：
  描述：

  [2-(3,5-bis-decyloxybenzyl)-3-(3,5-bis-decyloxyphenyl)-2-hydroxymethylpropyl]carbamic acid tert-butyl ester 在 2,6-二甲基吡啶 、 氨 作用下， 以 二氯甲烷 、 异丙醇 、 甲苯 为溶剂， 反应 21.0h， 生成 [3-(4-amino-6-chloro-[1,3,5]triazin-2-yloxy)-2,2-bis-(3,5-bis-decyloxybenzyl)propyl]carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthetic duplex oligomers: optimizing interstrand affinity through the use of a noncovalent constraint

  摘要：

  The covalent casting of a one-dimensional hydrogen-bonding motif permits the design of oligomers possessing a predetermined duplex mode of aggregation. In this account, studies on the hydrogen bond mediated self-assembly of dimeric duplex oligomers 2 in solution are described. Two-fold self-association in solution is established by H-1 NMR, and the intended mode of assembly is further corroborated via X-ray crystallographic analysis. An increase in interstrand affinity of over three orders of magnitude is observed upon substitution of nitrogen for oxygen in the oligomer backbone, owing to preorganization of the molecular strand in the binding effective conformation as directed by the formation of an internal hydrogen bond. These data provide insight into the structural and interactional features of the oligomers required for high affinity/specificity binding in organic media. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01090-0