(1R,3S)-5-bromo-1-[(3-hydroxymethyl-1,2,2-trimethyl)cyclopentylmethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione acetate | 443301-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (1R,3S)-5-bromo-1-[(3-hydroxymethyl-1,2,2-trimethyl)cyclopentylmethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione acetate
• CAS: 443301-08-4
• 化学式: C₁₆H₂₃BrN₂O₄
• 分子量: 387.274
• InChiKey: QXJWVAPGPNFRCA-BZNIZROVSA-N

反应信息

• 作为反应物：
  描述：

  (1R,3S)-5-bromo-1-[(3-hydroxymethyl-1,2,2-trimethyl)cyclopentylmethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione acetate 在 ammonium hydroxide 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以79%的产率得到5-bromo-1-(((1R,3S)-3-(hydroxymethyl)-1,2,2-trimethylcyclopentyl)methyl)pyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES, OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING. IV. ADENOSINE AND URIDINE ANALOGUES

  摘要：

  Eight new carbocyclic nucleosides were prepared by mounting a purine (compounds 8-10), 8-azapurine (12 and 13) or pyrimidine (15, 16 and 17b) on the amino group of (1S,3R)-3-aminomethyl-2,2,3-trimethyl-cyclopentylmethanol (6). All the compounds were evaluated as antiviral and antitumor agents in a variety of assay systems. Only compound 8 showed any cytostatic activity against the tumor cell lines examined.

  DOI：

  10.1081/ncn-120003289
• 作为产物：
  描述：

  (+)-(1R,3S)-N-[(3-hydroxymethyl-1,2,2-trimethyl)cyclopentylmethyl]-N'-(3-ethoxypropenoyl)urea 在 ammonium hydroxide 作用下， 反应 31.0h， 生成 (1R,3S)-5-bromo-1-[(3-hydroxymethyl-1,2,2-trimethyl)cyclopentylmethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione acetate
  参考文献：
  名称：

  SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES, OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING. IV. ADENOSINE AND URIDINE ANALOGUES

  摘要：

  Eight new carbocyclic nucleosides were prepared by mounting a purine (compounds 8-10), 8-azapurine (12 and 13) or pyrimidine (15, 16 and 17b) on the amino group of (1S,3R)-3-aminomethyl-2,2,3-trimethyl-cyclopentylmethanol (6). All the compounds were evaluated as antiviral and antitumor agents in a variety of assay systems. Only compound 8 showed any cytostatic activity against the tumor cell lines examined.

  DOI：

  10.1081/ncn-120003289