| 1191907-34-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• CAS: 1191907-34-2
• 化学式: C₂₄H₂₅F₃N₂O₃
• 分子量: 446.469
• InChiKey: WSSCBXUCVDQSDB-TXTKFYIRSA-N

反应信息

• 作为产物：
  描述：

  trans-2-(5-methyl-5-phenyl-4,5-dihydroisoxazol-3-yl)-N-(4-(trifluoromethoxy)benzyl)cyclopentanecarboxamide 生成 、 、 、
  参考文献：
  名称：

  Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

  摘要：

  Analogs of the previously reported voltage gated sodium channel blocker CDA54 were prepared in which one of the amide functions was replaced with aromatic and non-aromatic heterocycles. Replacement of the amide with an aromatic heterocycle resulted in significant loss of sodium channel blocking activity, while non-aromatic heterocycle replacements were well tolerated. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.125