4-Methyl-thiophene-2-carboxylic acid N'-[2-(3-amino-pyrrolidin-1-yl)-acetyl]-hydrazide | 774597-41-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Methyl-thiophene-2-carboxylic acid N'-[2-(3-amino-pyrrolidin-1-yl)-acetyl]-hydrazide
• CAS: 774597-41-0
• 化学式: C₁₂H₁₈N₄O₂S
• 分子量: 282.367
• InChiKey: YSXZURHJXHLYCL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-Methyl-thiophene-2-carboxylic acid N'-[2-(3-amino-pyrrolidin-1-yl)-acetyl]-hydrazide 、 alkaline earth salt of/the/ methylsulfuric acid 在 N,N-二异丙基乙胺 作用下， 生成 4-Methyl-thiophene-2-carboxylic acid N'-{2-[3-(4-chloro-benzylamino)-pyrrolidin-1-yl]-acetyl}-hydrazide
  参考文献：
  名称：

  Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure–activity relationships of diamine derivatives

  摘要：

  Structure-activity relationships (SAR) of a weakly active class of CCR2b inhibitors were utilized to initiate a ead evolution program employing the Drug Discovery Engine(TM). Several alternative structural series have been discovered that display nanomolar activity in the CCR2b binding and CCR2b-mediated chemotaxis assays. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.009
• 作为产物：
  描述：

  (1-{2-[N'-(4-Methyl-thiophene-2-carbonyl)-hydrazino]-2-oxo-ethyl}-pyrrolidin-3-yl)-carbamic acid tert-butyl ester 在 三氟乙酸 作用下， 生成 4-Methyl-thiophene-2-carboxylic acid N'-[2-(3-amino-pyrrolidin-1-yl)-acetyl]-hydrazide
  参考文献：
  名称：

  Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure–activity relationships of diamine derivatives

  摘要：

  Structure-activity relationships (SAR) of a weakly active class of CCR2b inhibitors were utilized to initiate a ead evolution program employing the Drug Discovery Engine(TM). Several alternative structural series have been discovered that display nanomolar activity in the CCR2b binding and CCR2b-mediated chemotaxis assays. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.009