(E)-2',2"-(1",4"-but-2"-enediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxyphenyl)methyl-2-methyl]isoquinoline | 1185180-09-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (E)-2',2"-(1",4"-but-2"-enediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxyphenyl)methyl-2-methyl]isoquinoline
• CAS: 1185180-09-9
• 化学式: C₄₆H₅₈N₂O₈
• 分子量: 766.975
• InChiKey: LQWUKVYNWXIGPX-VAWYXSNFSA-N

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 (Z)-2',2"-(1",4"-but-2"-enediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxyphenyl)methyl]isoquinoline 、 (E)-2',2"-(1",4"-but-2"-enediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxyphenyl)methyl]isoquinoline 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 18.3h， 生成 (Z)-2',2"-(1",4"-but-2"-enediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxyphenyl)methyl-2-methyl]isoquinoline 、 (E)-2',2"-(1",4"-but-2"-enediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxyphenyl)methyl-2-methyl]isoquinoline
  参考文献：
  名称：

  The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis

  摘要：

  Novel laudanosine dinners in which two laudanosine units are linked at C-2' via a two and four-carbon linker have been prepared using ruthenium-mediated olefin-metathesis. In addition, a second four-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Five of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.094