| 1174735-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• CAS: 1174735-72-8
• 化学式: C₈H₁₂N₂O₂S₂
• 分子量: 232.327
• InChiKey: RJHHHWWVDJOQQO-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-氯乙酰乙酸乙酯 、 在 溶剂黄146 作用下， 以 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure–activity relationships of benzothiazine-substituted quinolinediones

  摘要：

  A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar potencies in the HCV cell based replicon assay. Pharmacokinetic and toxicology studies were also performed on a selected compound (34) to evaluate in vivo properties of this new class of inhibitors of HCV NS5B polymerase.

  DOI：

  10.1016/j.bmcl.2009.05.004