TIGGIR-OEt-SH | 1300037-67-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: TIGGIR-OEt-SH
• CAS: 1300037-67-5
• 化学式: C₂₈H₅₃N₉O₈S
• 分子量: 675.85
• InChiKey: AOVQZQHYJWPXOW-LYANZRBVSA-N

反应信息

• 作为产物：
  描述：

  2-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethyl-[12-[2-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethyl-(2-hydroxyethyl)-methylazaniumyl]dodecyl]-(2-hydroxyethyl)-methylazanium 在 三氟乙酸 作用下， 生成 、 TIGGIR-OEt-SH
  参考文献：
  名称：

  Acid-Catalyzed Tandem Thiol Switch for Preparing Peptide Thioesters from Mercaptoethyl Esters

  摘要：

  An efficient method compatible with Fmoc synthesis for preparing peptide thioesters via an acid-catalyzed tandem "thiol switch" of esters Is described first by an intramolecular O-S acyl shift and then by an intermolecular S S exchange, with concurrent deblocking of side chain protection groups.

  DOI：

  10.1021/ol2007204