(3-aminopropyl)(2-carboxy-4-methylpentyl)phosphinic acid hydrochloride | 1160184-48-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (3-aminopropyl)(2-carboxy-4-methylpentyl)phosphinic acid hydrochloride
• CAS: 1160184-48-4
• 化学式: C₁₀H₂₂NO₄P*ClH
• 分子量: 287.724
• InChiKey: ODGVGWBUJNMMGY-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 盐酸 、 水 作用下， 反应 15.0h， 生成 (3-aminopropyl)(2-carboxy-4-methylpentyl)phosphinic acid hydrochloride
  参考文献：
  名称：

  A method of synthesis of phosphinic acids on the basis of hypophosphites: VII. Synthesis of pseudo-γ-aminobutanoyl peptides and other phosphinic analogs of γ-aminobutyric acid

  摘要：

  A method of synthesis of pseudo-gamma-aminobutanoyl peptides and other phosphinic analogs of gamma-aminobutyric acid from hypophosphites is suggested. Silyl phosphonites formed by in situ addition of bis-(trimethylsilyl) hypophosphite to the corresponding alpha-substituted acrylates, styrene, or vinyl phosphonate used as unsaturated components in the synthesis react in situ with N-(omega-bromoalkyl)phthalimides by an Arbuzov reaction scheme, affording omega-(phthalimido)alkylphosphinic acids possessing beta-substituted beta-(alkoxycarbonyl)ethyl, beta-phenylethyl, or beta-(diethoxyphosphinoyl)ethyl substituents. Acid hydrolysis of these reaction products gives the target aminophosphinic acids: phosphinic analogs of gamma-aminobutyric acid.

  DOI：

  10.1134/s107036320809003x