In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
摘要:
Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H-3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine. (C) 2007 Elsevier Ltd. All rights reserved.
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
摘要:
Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H-3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine. (C) 2007 Elsevier Ltd. All rights reserved.