5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-3-[(2R)-2-(methylamino)-2-phenylethyl]pyrimidine-2,4-dione | 1062642-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-3-[(2R)-2-(methylamino)-2-phenylethyl]pyrimidine-2,4-dione
• CAS: 1062642-62-9
• 化学式: C₂₉H₂₆F₅N₃O₃
• 分子量: 559.536
• InChiKey: CDRAQXLKOIEQLJ-QHCPKHFHSA-N

物化性质

• 沸点：
  623.8±65.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-3-[(2R)-2-(methylamino)-2-phenylethyl]pyrimidine-2,4-dione 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 C₂₈H₂₄F₅N₃O₃
  参考文献：
  名称：

  Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties

  摘要：

  A novel series of potent zwitterionic uracil GnRH antagonists were discovered that showed reduced liability for CYP3A4 enzyme inhibition. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.059

文献信息

• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF ELAGOLIX SODIUM<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION D'ÉLAGOLIX SODIQUE
  申请人：NEULAND LABORATORIES LTD

  公开号：WO2021064561A1

  公开（公告）日：2021-04-08

  An improved process for the preparation of Elagolix Sodium having the structural formula (I). The present invention relates to highly pure compound of formula (VI) as a solid which is useful in the preparation of Elagolix sodium. The present invention provides a stable, simple and commercially viable improved process for the preparation of Elagolix sodium of formula (I). The present invention also provides novel crystalline form-N of compound of formula (Vl) which is used in the preparation of Elagolix sodium of formula-I.

  一种改进的制备Elagolix Sodium（结构式（I））的工艺。本发明涉及公式（VI）的高纯度化合物，作为固体在制备Elagolix sodium中有用。本发明提供了一种稳定、简单和商业可行的改进工艺，用于制备公式（I）的Elagolix sodium。本发明还提供了公式（Vl）化合物的新晶体形态-N，该形态用于制备公式-I的Elagolix sodium。