| 57901-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 57901-68-5
• 化学式: C₁₂H₁₆BrN₃O₅
• 分子量: 362.18
• InChiKey: NOBKWEJMOJAXQQ-FDDDBJFASA-N

反应信息

• 作为反应物：
  描述：

  在 ammonium hydroxide 、 碘 作用下， 反应 4.0h， 以63%的产率得到5-bromo-2',3'-O-isopropylidene-O⁶,5'-cyclocytidine
  参考文献：
  名称：

  A Novel One-Step Method for the Synthesis of C-5-Substituted O⁶,5‘-Cyclopyrimidine Nucleoside Analogues in Ammonia Water

  摘要：

  A novel one-step method for preparing C-5-substituted O-6,5'-cyclopyrimidine nucleoside analogues is reported. This method employs molecular iodine to mediate the cyclization from the 5'-O-hydroxyl group of the sugar ring and C-6 at the position of the nitrogen base in ammonia water under mild conditions without any other aprotic organic solvent.

  DOI：

  10.1021/jo7026245