8-2'-Anhydro-8-oxy-9-β-D-arabinofuranosyladenin-3',5' cyclische Phosphorauere | 39947-18-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物
• 英文名称: 8-2'-Anhydro-8-oxy-9-β-D-arabinofuranosyladenin-3',5' cyclische Phosphorauere
• 英文别名: 8,2'-O-Cycloadenosin-3',5'-cyclophosphat；8,2'-anhydro-8-oxy-9β-D-arabinofuranosyl-adenin-3',5'-cyclicphosphat；8,2'-Anhydro-8-oxy-9β-D-arabinofuranosyladenin-3',5'-cycl.phosphat；(4aR)-10-amino-2-oxo-(4ar,5ac,12ac,12bt)-4a,5a,12a,12b-tetrahydro-4H-[1,3,2]dioxaphosphinino[4'',5'':4',5']furo[2',3':4,5]oxazolo[3,2-e]purin-2-ol；O^{3'_,O5'_{-hydroxyphosphoryl-arabino-8,O}2'}-cyclo-adenosine
• CAS: 39947-18-7
• 化学式: C₁₀H₁₀N₅O₆P
• 分子量: 327.193
• InChiKey: YXYOSHXTPNFEAA-FJFJXFQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.42
• 重原子数：
  22.0
• 可旋转键数：
  0.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  143.84
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  phosphoric acid mono-[(6aS)-4-amino-8t-(4-methoxy-trityloxymethyl)-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-e]purin-7c-yl] ester 在 吡啶 、 morpholino-N,N'-dicyclohexylcarboxyamidine 、 水 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 生成 8-2'-Anhydro-8-oxy-9-β-D-arabinofuranosyladenin-3',5' cyclische Phosphorauere
  参考文献：
  名称：

  Polynucleotides. XXVI. Synthesis of an AUG analog, 8,2'-anhydro-8-oxy-9-.BETA.-D-arabinofuranosyladenine phosphoryl-(3'-5')-uridylyl-(3'-5')-guanosine.

  摘要：

  A triplet AUG analog containing 8, 2'-O-cycloadenosine in the first position was synthesized. Starting from 2'-O-(2, 4, 6-triisopropylbenzenesulfonyl)-8-bromoadenosine (I), 5'-monomethoxytrityl-8, 2'-O-cycloadenosine (IV) was synthesized via 8-oxy derivative (II) by the successive treatment with sodium acetate, monomethoxytrityl chloride and methanolic ammonia. Phosphorylation of compound IV with cyanoethyl phosphate and dicyclohexylcarbodiimide (DCC) at 18-20° for 5 days gave only 3'-cyanoethylphosphate (V) quantitatively. Treatment of V with methanolic ammonia gave 3'-phosphate (VI) in a relatively low yield with concomitant formation of 2', 3'-cyclic phosphate (VII). Compound VI was then condensed with 2'-O-benzoyluridylyl-(3'-5')-N2, 2', 3'-triisobutyrylguanosine (X) using DCC and after purification on a column of diethylaminoethyl (DEAE)-cellulose, 8, 2'-O-cycloadenylyl-(3'-5')-guanosine (XI) was obtained in a yield of 4.1%. Compound XI showed hypochromicity of 7.3% at 257 nm and circular dichroism (CD) spectra taken at 0° and 20° revealed that this trinucleotide exists in a rather freely rotatable, unstacked form both at these temperatures.

  DOI：

  10.1248/cpb.22.2578