| 1114400-68-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1114400-68-8
• 化学式: C₂₅H₄₇NO₅
• 分子量: 441.652
• InChiKey: JYHXNHRGVHYNKW-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.79
• 重原子数：
  31.0
• 可旋转键数：
  19.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  92.7
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  Fmoc-cysteine-(S-farnesyl) resin 在 戴斯-马丁氧化剂 作用下， 生成
  参考文献：
  名称：

  Synthesis and application in SPPS of a stable amino acid isostere of palmitoyl cysteine

  摘要：

  (S)-2-Amino-4-(2-pentadecyl-1,3-dioxolan-2-yl)-butanoic acid, 11, Pdiob, a synthetic analogue C-isostere of palmitoylated cysteine, has been prepared starting from tetrabenzyl glutamic acid. The less hindered benzyl carboxylate ester was transformed into the corresponding beta-ketophosphonate and subjected to a Horner-Wadsworth-Emmons reaction followed by hydrogenation/hydrogenolysis. This product was used for the preparation on solid phase and under microwave dielectric heating of a highly lipidated peptide that can be considered as an acid stable analogue of the C-terminus of the H-Ras heptapeptides 180-186. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.033