2-(N-methylbenzamido)-5-(3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranosyl)thiazole | 1029931-25-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(N-methylbenzamido)-5-(3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranosyl)thiazole
• CAS: 1029931-25-6
• 化学式: C₄₉H₅₄N₂O₅SSi₂
• 分子量: 839.215
• InChiKey: JUJVXPLWARONHL-DIAWZIJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.15
• 重原子数：
  59.0
• 可旋转键数：
  12.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  70.12
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-(N-methylbenzamido)-5-(3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranosyl)thiazole 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以72%的产率得到2-(N-methylbenzamido)-5-(2-O,4-C-methylene-D-ribofuranosyl)thiazole
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043
• 作为产物：
  描述：

  2-(N-methylbenzamido)-5-(3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribitol-1-yl)thiazole 在 三丁基膦 、 偶氮二甲酰胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以64%的产率得到2-(N-methylbenzamido)-5-(3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranosyl)thiazole
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043