4-(benzylsulfonyl)-3H-1,2,3-triazole | 79100-71-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(benzylsulfonyl)-3H-1,2,3-triazole
• 英文别名: NoName_1617；4-benzylsulfonyl-2H-triazole
• CAS: 79100-71-3
• 化学式: C₉H₉N₃O₂S
• 分子量: 223.255
• InChiKey: JRDBKQITQPXRMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  75.71
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  5-Benzylsulfanyl-1H-[1,2,3]triazole 在 双氧水 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 40.0h， 生成 4-(benzylsulfonyl)-3H-1,2,3-triazole
  参考文献：
  名称：

  A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate

  摘要：

  A systematic approach to the replacement of acidic groups with potential bioisosteres is described. The strategy involves simple nucleophilic displacement of a common alkyl halide precursor with a variety of mercaptoazoles and related molecules. The mercaptoazoles and their oxidized derivatives (sulfinyl- and sulfonylazoles) represent a series of possible surrogates for acidic groups which span a pKa range from about 4.5-11.5. This simple strategy was extended to include 2-hydroxy- or 2-aminothiophenyl groups which function as relatively nonacidic isosteres for a phosphonic acid. By replacing the phosphonic acid of 2-amino-7-phosphonoheptanoate (AP-7) with these groups, we have synthesized novel N-methyl-d-aspartate (NMDA) antagonists.

  DOI：

  10.1021/jm00165a030

文献信息

• METAL-POLISHING COMPOSITION AND CHEMICAL MECHANICAL POLISHING METHOD BY USING THE SAME
  申请人：KATO Tomoo

  公开号：US20080188079A1

  公开（公告）日：2008-08-07

  The present invention provides a metal-polishing composition for use in chemical mechanical polishing of semiconductor devices, comprising: (a) a compound represented by the following Formula A, (b) a compound represented by the following Formula B, (c) an abrasive grain, and (d) an oxidizing agent: in Formula A, R 1 represents an alkyl group having 1 to 3 carbon atoms; and R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and in Formula B, R 3 , R 4 , and R 5 each independently represent a hydrogen atom, or an alkyl, aryl, alkoxy, amino, aminoalkyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl or carbamoyl group.
• A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate
  作者：B. L. Chenard、C. A. Lipinski、B. W. Dominy、E. E. Mena、R. T. Ronau、G. C. Butterfield、L. C. Marinovic、M. Pagnozzi、T. W. Butler、T. Tsang

  DOI：10.1021/jm00165a030

  日期：1990.3

  A systematic approach to the replacement of acidic groups with potential bioisosteres is described. The strategy involves simple nucleophilic displacement of a common alkyl halide precursor with a variety of mercaptoazoles and related molecules. The mercaptoazoles and their oxidized derivatives (sulfinyl- and sulfonylazoles) represent a series of possible surrogates for acidic groups which span a pKa range from about 4.5-11.5. This simple strategy was extended to include 2-hydroxy- or 2-aminothiophenyl groups which function as relatively nonacidic isosteres for a phosphonic acid. By replacing the phosphonic acid of 2-amino-7-phosphonoheptanoate (AP-7) with these groups, we have synthesized novel N-methyl-d-aspartate (NMDA) antagonists.