| 1018689-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1018689-69-4
• 化学式: C₃₀H₅₄O₆Si
• 分子量: 538.841
• InChiKey: KLSZOYXEGXKJOL-XUEBXJBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.55
• 重原子数：
  37.0
• 可旋转键数：
  21.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  63.22
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (R,E)-1-iodo-4-(methoxymethoxy)-2-methylhept-1-ene 、 在 叔丁基锂 作用下， 以 乙醚 、 正戊烷 为溶剂， 反应 1.42h， 生成 (5R,9R,10R,11S,13R,E)-15,15-diisopropyl-13-(5-(4-methoxybenzyloxy)pentyl)-11-(methoxymethoxy)-7,10,16-trimethyl-5-propyl-2,4,14-trioxa-15-silaheptadec-7-en-9-ol 、 (5R,9S,10R,11R,13R,E)-15,15-diisopropyl-13-(5-(4-methoxybenzyloxy)pentyl)-9-(methoxymethoxy)-7,10,16-trimethyl-5-propyl-2,4,14-trioxa-15-silaheptadec-7-en-11-ol
  参考文献：
  名称：

  A Multifaceted Phosphate Tether:  Application to the C15−C30 Subunit of Dolabelides A−D

  摘要：

  Construction of the C15-C30 subunit of dolabelide utilizing a temporary phosphate tether is described. Two routes are reported that make use of the orthogonal protecting- and leaving-group properties innate to phosphate esters. One route relies on a selective terminal oxidation, while a second utilizes a CM/selective hydrogenation sequence. Both routes depend on a highly regio- and diastereoselective cuprate addition to set the requisite stereochemistry at C22.

  DOI：

  10.1021/ol8001865
• 作为产物：
  描述：

  (5S,7R)-5-((R)-but-3-en-2-yl)-9,9-diisopropyl-7-(5-(4-methoxybenzyloxy)pentyl)-10-methyl-2,4,8-trioxa-9-silaundecane 在 二甲基硫 、 臭氧 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到
  参考文献：
  名称：

  A Multifaceted Phosphate Tether:  Application to the C15−C30 Subunit of Dolabelides A−D

  摘要：

  Construction of the C15-C30 subunit of dolabelide utilizing a temporary phosphate tether is described. Two routes are reported that make use of the orthogonal protecting- and leaving-group properties innate to phosphate esters. One route relies on a selective terminal oxidation, while a second utilizes a CM/selective hydrogenation sequence. Both routes depend on a highly regio- and diastereoselective cuprate addition to set the requisite stereochemistry at C22.

  DOI：

  10.1021/ol8001865