| 914936-64-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• CAS: 914936-64-4
• 化学式: C₅₂H₈₇NO₆SSi₂
• 分子量: 910.503
• InChiKey: JLDOGKWZUXQSEC-QFYAZBHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.76
• 重原子数：
  62.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  87.11
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  在 氟化氢吡啶 作用下， 以 四氢呋喃 为溶剂， 以83%的产率得到1'-descarbamoyl-archazolid A
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel analogues of archazolid: A highly potent simplified V-ATPase inhibitor

  摘要：

  Novel analogues of the V-ATPase inhibitors archazolid A and B with modifications of the free hydroxyl groups and the side chain were designed by molecular modeling, synthesized by derivatization of the parent natural product and evaluated for V-ATPase inhibition and growth inhibition of murine connective tissue cells. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.073
• 作为产物：
  描述：

  (7,15)-bis-O-TBS-ether of archazolid A 在 三氯硅烷 、 三乙胺 作用下， 以 甲苯 为溶剂， 以91%的产率得到
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel analogues of archazolid: A highly potent simplified V-ATPase inhibitor

  摘要：

  Novel analogues of the V-ATPase inhibitors archazolid A and B with modifications of the free hydroxyl groups and the side chain were designed by molecular modeling, synthesized by derivatization of the parent natural product and evaluated for V-ATPase inhibition and growth inhibition of murine connective tissue cells. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.073