(S)-pyrrolidine-2-carboxylic acid [6-(quinolin-8-yloxymethyl)pyridin-2yl]amide | 1262220-06-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-pyrrolidine-2-carboxylic acid [6-(quinolin-8-yloxymethyl)pyridin-2yl]amide
• CAS: 1262220-06-3
• 化学式: C₂₀H₂₀N₄O₂
• 分子量: 348.404
• InChiKey: QLJXCACLGCVXJI-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  76.14
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  8-(6-bromomethylpyridin-2ylmethoxy)quinoline 、 (S)-pyrrolidine-2-carboxylic acid [6-(quinolin-8-yloxymethyl)pyridin-2yl]amide 在 四丁基溴化铵 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以60%的产率得到(S)-1-[6-(quinolin-8-yloxymethyl)pyridin-2-ylmethyl]pyrrolidine-2-carboxylic acid [6-(quinolin-8-yloxymethyl)pyridin-2-yl]amide
  参考文献：
  名称：

  Metal ion based chiral fluorescence sensor selective for dihydrogenphosphate

  摘要：

  A Cu(II) based conformationally restricted chiral fluorescence sensor (receptor 2) has been designed and synthesized for selective sensing of anions. The anion recognition property of the Cu2+-complex has been studied in acetonitrile by fluorescence methods which show remarkable sensitivity toward dihydrogen phosphate via fluorescence modulation of the Cu2+-complex over the other anions examined. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.034
• 作为产物：
  描述：

  (S)-2-[6-(quinolin-8-yloxymethyl)pyridin-2-ylcarbamoyl]pyrrolidine-1-carboxylic acid tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以90%的产率得到(S)-pyrrolidine-2-carboxylic acid [6-(quinolin-8-yloxymethyl)pyridin-2yl]amide
  参考文献：
  名称：

  Metal ion based chiral fluorescence sensor selective for dihydrogenphosphate

  摘要：

  A Cu(II) based conformationally restricted chiral fluorescence sensor (receptor 2) has been designed and synthesized for selective sensing of anions. The anion recognition property of the Cu2+-complex has been studied in acetonitrile by fluorescence methods which show remarkable sensitivity toward dihydrogen phosphate via fluorescence modulation of the Cu2+-complex over the other anions examined. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.034