N-{2-[2-(4-Bromo-phenylazo)-1H-imidazol-4-yl]-ethyl}-acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{2-[2-(4-Bromo-phenylazo)-1H-imidazol-4-yl]-ethyl}-acetamide
• 化学式: C₁₃H₁₄BrN₅O
• 分子量: 336.191
• InChiKey: GGZSHVUZOINSCW-VHEBQXMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  20.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  82.5
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N-{2-[2-(4-Bromo-phenylazo)-1H-imidazol-4-yl]-ethyl}-acetamide 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 以81%的产率得到α-N-Acetyl-2-aminohistamin
  参考文献：
  名称：

  Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors

  摘要：

  The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compounds. By correctly selecting the combination of P1 and P3 residues, high levels of potency, selectivity and in vivo efficacy were obtained. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00131-2
• 作为产物：
  描述：

  Nω-乙酰基组胺 、 4-溴苯胺 在 盐酸 、 sodium nitrite 、 sodium carbonate 、 sodium hydroxide 作用下， 以30%的产率得到N-{2-[2-(4-Bromo-phenylazo)-1H-imidazol-4-yl]-ethyl}-acetamide
  参考文献：
  名称：

  Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors

  摘要：

  The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compounds. By correctly selecting the combination of P1 and P3 residues, high levels of potency, selectivity and in vivo efficacy were obtained. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00131-2

文献信息

• [EN] AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR DE LA PROKINÉTICINE 1 À TENEUR EN AMINO-HÉTÉROARYLE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009058653A1

  公开（公告）日：2009-05-07

  The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.

  本发明涉及某些新型化合物的公式（I）以及制备这些化合物、组合物、中间体和衍生物的方法，用于治疗促动素1或促动素1受体介导的疾病。
• AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2215067A1

  公开（公告）日：2010-08-11
• US8324380B2
  申请人：——

  公开号：US8324380B2

  公开（公告）日：2012-12-04
• Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors
  作者：Yves St-Denis、Sophie Lévesque、Benoit Bachand、Jeremy J Edmunds、Lorraine Leblond、Patrice Préville、Micheline Tarazi、Peter D Winocour、M.Arshad Siddiqui

  DOI：10.1016/s0960-894x(02)00131-2

  日期：2002.4

  The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compounds. By correctly selecting the combination of P1 and P3 residues, high levels of potency, selectivity and in vivo efficacy were obtained. (C) 2002 Elsevier Science Ltd. All rights reserved.