14-hydroxy-tetradeca-4,6,10,12-tetrayne-8-enoic acid | 155626-11-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 14-hydroxy-tetradeca-4,6,10,12-tetrayne-8-enoic acid
• CAS: 155626-11-2
• 化学式: C₁₄H₁₀O₃
• 分子量: 226.232
• InChiKey: OBINASOLYFHLBO-IWQZZHSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.41
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  57.53
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  14-hydroxy-tetradeca-4,6,10,12-tetrayne-8-enoic acid 在 N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride 、 三乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 以24%的产率得到(Z)-Oxacyclopentadec-9-ene-5,7,11,13-tetrayn-2-one
  参考文献：
  名称：

  Synthesis and investigations of enetetraynes

  摘要：

  Several enetetrayne containing compounds have been synthesized and their chemistry explored vis-a-vis the Bergman cycloaromatization. With one exception the compounds were unreactive along this pathway. AM1 calculations were performed in order to gain further insights into these reactions. The results indicate that the strain of constraining the resulting benzodiyne in a small ring raises the energy of the transition state of the initial Bergman reaction.

  DOI：

  10.1016/s0040-4020(01)80631-1
• 作为产物：
  描述：

  methyl tetradeca-4,6,10,12-tetrayne-8-enoate-14-tetrahydropyranyl ether 在 lithium hydroxide 、 Dowex 50w X 8 HCl 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 生成 14-hydroxy-tetradeca-4,6,10,12-tetrayne-8-enoic acid
  参考文献：
  名称：

  Synthesis and investigations of enetetraynes

  摘要：

  Several enetetrayne containing compounds have been synthesized and their chemistry explored vis-a-vis the Bergman cycloaromatization. With one exception the compounds were unreactive along this pathway. AM1 calculations were performed in order to gain further insights into these reactions. The results indicate that the strain of constraining the resulting benzodiyne in a small ring raises the energy of the transition state of the initial Bergman reaction.

  DOI：

  10.1016/s0040-4020(01)80631-1